| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IGFLR1 |
| Uniprot No | Q9H665 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-163aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSSQYCGRLEYWNPDNKCCSSCLQRFGPP PCPDYEFRENCGLNDHGDFVTPPFRKCSSGQCNPDGAELCSPCGGGAVTP TPAAGGGRTPWRCRERPVPAKGHCPLTPGNPGAPSSQERSSPASSIAWRT PEPVPQQAWPNFLP |
| 预测分子量 | 18 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IGFLR1重组蛋白的虚构参考文献示例(仅供格式参考)：
1. **文献名称**：*Recombinant IGFLR1 Protein Promotes Neuronal Survival via Akt Signaling*
**作者**：Zhang Y, et al.
**摘要**：研究在大肠杆菌中成功表达并纯化IGFLR1重组蛋白，证实其通过激活Akt信号通路促进神经元存活，提示其在神经退行性疾病中的潜在治疗作用。
2. **文献名称**：*Structural Characterization of IGFLR1 and Its Interaction with Integrins*
**作者**：Lee S, et al.
**摘要**：通过X射线晶体学解析了IGFLR1重组蛋白的三维结构，发现其富含亮氨酸重复序列的结构域介导与整合素α5β1的结合，可能参与细胞黏附调控。
3. **文献名称**：*IGFLR1 Recombinant Protein Attenuates Colitis in Murine Models*
**作者**：Wang H, et al.
**摘要**：在小鼠结肠炎模型中，腹腔注射重组IGFLR1蛋白显著减轻炎症反应，机制可能与抑制NF-κB通路及调节肠道免疫细胞平衡相关。
4. **文献名称**：*Expression and Functional Analysis of IGFLR1 in Cancer Cell Migration*
**作者**：Gupta R, et al.
**摘要**：在乳腺癌细胞系中，重组IGFLR1蛋白通过激活ERK1/2信号通路增强细胞迁移能力，提示其可能作为癌症治疗的潜在靶点。
注：以上内容为模拟示例，实际文献需通过学术数据库检索确认。
**Background of IGFLR1 Recombinant Protein**
IGFLR1 (Immunoglobulin Superfamily Leucine-Rich Repeat protein 1) is a transmembrane or secreted protein belonging to the IGFL family, which shares structural homology with insulin-like growth factor (IGF) and epidermal growth factor (EGF) signaling components. It contains conserved immunoglobulin (Ig) domains and leucine-rich repeats (LRRs), suggesting roles in cell-cell interactions, ligand recognition, or receptor binding. IGFLR1 is encoded by the *IGFLR1* gene, located in humans on chromosome 19. and is expressed in various tissues, including the skin, immune cells, and developing organs.
Functionally, IGFLR1 is implicated in regulating cellular processes such as proliferation, differentiation, and survival. Studies suggest its involvement in immune modulation, tissue repair, and cancer progression. For instance, IGFLR1 may interact with extracellular matrix components or cell-surface receptors to activate signaling pathways like MAPK/ERK or PI3K/Akt, though its precise mechanisms remain under investigation.
Recombinant IGFLR1 protein is engineered for research and therapeutic applications. Produced via heterologous expression systems (e.g., mammalian cells, *E. coli*), it retains functional domains for in vitro and in vivo studies. Purified recombinant IGFLR1 is used to study ligand-receptor interactions, screen for therapeutic antibodies, or explore its role in diseases like cancer, fibrosis, or inflammatory disorders. Its potential as a biomarker or therapeutic target is an active area of research, particularly in oncology and regenerative medicine.
Overall, IGFLR1 represents a promising yet underexplored protein with diverse biological and clinical relevance, warranting further mechanistic and translational studies.
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