| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HO-1; HSP32; HMOX1D; bK286B10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HMOX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HMOX1抗体的3篇参考文献及其简要摘要概括：
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1. **"Heme Oxygenase-1: A Novel Target for Cancer Therapy"**
*作者：S. W. Ryter, A. M. K. Choi (2016)*
摘要：研究探讨HMOX1在肿瘤微环境中的双重作用(促生存与促凋亡)，通过Western blot和免疫组化检测HMOX1表达，验证其在氧化应激下的调控机制，并强调抗体特异性对结果分析的重要性。
2. **"A Monoclonal Antibody for Heme Oxygenase-1: Tool Development and Applications in Ischemic Injury Models"**
*作者：L. E. Otterbein et al. (2005)*
摘要：描述一种新型抗HMOX1单克隆抗体的开发，通过免疫印迹和免疫荧光验证其特异性，应用于小鼠缺血再灌注损伤模型，揭示HMOX1在组织修复中的时空表达模式。
3. **"HMOX1 Induction as a Protective Response in Neurodegenerative Disorders"**
*作者：P. Piantadosi et al. (2008)*
摘要：研究HMOX1在阿尔茨海默病模型中的神经保护作用，利用特异性抗体进行脑组织免疫染色，发现其表达与氧化损伤程度相关，提示其作为治疗靶点的潜力。
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以上文献涵盖抗体开发、疾病机制研究和不同实验方法(如Western blot、免疫组化)，可为基础研究和临床应用提供参考。如需扩展，建议通过PubMed/Google Scholar以“HMOX1 antibody applications”为关键词筛选近五年研究。
**Background of HMOX1 Antibody**
HMOX1 (heme oxygenase 1) is an inducible enzyme that catalyzes the degradation of heme into biliverdin, carbon monoxide, and free iron, playing a critical role in cellular stress response, antioxidant defense, and inflammation regulation. It is upregulated under oxidative stress, hypoxia, or inflammatory conditions, primarily through the Nrf2/ARE signaling pathway. HMOX1 is implicated in various physiological and pathological processes, including cardiovascular diseases, neurodegenerative disorders, and cancer, where its expression often correlates with cytoprotective or pro-survival mechanisms.
The HMOX1 antibody is a key tool for detecting and quantifying HMOX1 protein levels in research. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression, subcellular localization, and regulatory mechanisms of HMOX1 under stress or disease conditions. Specificity is crucial, as HMOX1 shares structural homology with its constitutive isoform, HMOX2. High-quality antibodies are validated to distinguish between these isoforms and ensure cross-reactivity across species (e.g., human, mouse, rat).
Research utilizing HMOX1 antibodies has advanced understanding of its dual roles—protecting against oxidative damage while potentially contributing to disease progression in contexts like cancer chemoresistance. This highlights its therapeutic relevance and the importance of reliable antibody tools in biomedical studies.
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