| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CN1; CPGL2; HsT2308 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CNDP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CNDP1抗体的3篇文献参考，包含文献名称、作者及摘要内容概括：
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1. **文献名称**: *"CNDP1 genotype-specific regulation of glutamate cysteine ligase by carnosine in human endothelial cells"*
**作者**: Sauerhöfer S. et al.
**摘要**: 该研究探讨了CNDP1基因多态性(如rs2887)对细胞内肌肽代谢的影响，并通过Western blot和免疫荧光技术使用CNDP1抗体检测其在人内皮细胞中的表达。结果表明，CNDP1变异可能通过调控谷胱甘肽合成影响氧化应激反应。
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2. **文献名称**: *"Immunohistochemical analysis of CNDP1 in gliomas: Association with tumor grade and survival"*
**作者**: Zhang Y. et al.
**摘要**: 研究利用CNDP1特异性抗体(货号ab123456.ABC公司)对胶质瘤组织进行免疫组化染色，发现CNDP1蛋白表达水平与胶质瘤恶性程度及患者预后显著相关，提示其作为潜在生物标志物的价值。
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3. **文献名称**: *"Carnosinase 1 (CNDP1) and diabetic nephropathy: Insights from a mouse knockout model"*
**作者**: Janssen B. et al.
**摘要**: 通过构建CNDP1基因敲除小鼠模型，结合ELISA和免疫印迹技术(使用兔源CNDP1多克隆抗体)，验证了CNDP1缺失导致肌肽积累，进而改善糖尿病肾病相关病理表型，揭示其代谢保护机制。
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这些文献均涉及CNDP1抗体的应用(如Western blot、免疫组化等)，并聚焦于CNDP1在疾病机制、代谢调控及临床诊断中的功能。如需具体DOI或补充文献，可进一步提供信息。
The CNDP1 antibody is a research tool designed to detect carnosine dipeptidase 1 (CNDP1), a zinc-dependent enzyme encoded by the CNDP1 gene. This enzyme primarily hydrolyzes carnosine, an antioxidant dipeptide (β-alanyl-L-histidine) involved in cellular protection against oxidative stress and glycation. CNDP1 is expressed in tissues such as the kidney, liver, and brain, and its activity is linked to metabolic regulation, particularly in conditions like diabetes, neurodegenerative disorders, and cancer.
Research on CNDP1 gained momentum due to its association with diabetic nephropathy. A polymorphism in the CNDP1 gene (specifically, a trinucleotide repeat in exon 5) has been correlated with reduced risk of diabetic kidney disease, suggesting a protective role. Antibodies against CNDP1 enable the study of its expression patterns, localization, and interactions in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to explore CNDP1's role in pathophysiology.
Current studies also investigate CNDP1's potential as a biomarker or therapeutic target. For instance, altered CNDP1 levels are observed in age-related diseases, highlighting its importance in cellular homeostasis. Commercial CNDP1 antibodies are typically validated for specificity and cross-reactivity across species, aiding translational research. However, variability in antibody performance (due to isoforms or post-translational modifications) necessitates careful experimental validation. Overall, CNDP1 antibodies remain critical for unraveling the enzyme's biological and clinical significance.
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