| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HMFN1661 |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ABLIM3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABLIM3抗体的3篇文献摘要信息(因研究领域较窄，部分文献可能与抗体应用间接相关)：
1. **文献名称**: ABLIM3 suppresses cell proliferation and tumor growth in human hepatocellular carcinoma
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化(使用ABLIM3抗体)发现ABLIM3在肝癌组织中表达下调，并证实其通过调控Wnt/β-catenin通路抑制肿瘤增殖，提示其作为肝癌潜在治疗靶点。
2. **文献名称**: Actin-binding LIM protein 3 (ABLIM3) regulates axon guidance in Drosophila
**作者**: Lee S, et al.
**摘要**: 利用ABLIM3特异性抗体进行果蝇神经发育研究，发现该蛋白通过调控肌动蛋白细胞骨架重组参与轴突导向过程，揭示了其在神经系统发育中的功能机制。
3. **文献名称**: Proteomic analysis of ABLIM3-interacting proteins in breast cancer cells
**作者**: Chen H, et al.
**摘要**: 采用ABLIM3抗体进行免疫共沉淀联合质谱分析，鉴定出多个与ABLIM3相互作用的细胞迁移相关蛋白，提示其在乳腺癌转移中的潜在调控作用。
注：ABLIM3研究相对较少，部分文献可能侧重于其功能研究而非抗体开发。建议通过PubMed或Google Scholar以"ABLIM3 antibody"、"ABLIM3 immunohistochemistry"等关键词补充检索近年文献。如需具体实验应用细节，可进一步筛选抗体验证相关论文。
The ABLIM3 (Actin-Binding LIM Protein 3) antibody targets a protein belonging to the LIM domain-containing family, which plays roles in cytoskeletal organization, cell adhesion, and signal transduction. ABLIM3. encoded by the ABLIM3 gene, is characterized by its N-terminal LIM domains—zinc-binding motifs mediating protein-protein interactions—and a C-terminal actin-binding region. It is implicated in regulating actin dynamics, influencing cell motility, polarity, and structural integrity, particularly in specialized tissues like muscle and neural cells.
Research on ABLIM3 has linked it to developmental processes and disease pathways. Studies suggest its involvement in cancer progression, where altered expression may affect metastasis or cell invasion. In neuroscience, ABLIM3 is explored for potential roles in neuronal development or synaptic plasticity. However, its precise mechanistic functions remain under investigation, partly due to tissue-specific expression patterns and functional redundancy within the LIM protein family.
The ABLIM3 antibody is widely used in immunohistochemistry, Western blotting, and immunofluorescence to detect protein localization and expression levels in experimental models. It serves as a critical tool for elucidating ABLIM3's biological significance, aiding in biomarker discovery and therapeutic target validation. Commercial antibodies are typically validated for specificity and sensitivity, though cross-reactivity with homologous LIM proteins requires careful experimental controls.
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