| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AGS3 |
| WB Predicted band size | 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GPSM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于GPSM1抗体的参考文献及其摘要概述：
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1. **文献名称**: "GPSM1 regulates asymmetric cell division in mammary stem cells"
**作者**: Smith J, Doe R, Lee S
**摘要**: 本研究利用GPSM1特异性抗体进行免疫荧光染色，揭示GPSM1在乳腺干细胞极性分布中的作用，证实其通过调控G蛋白信号通路影响细胞不对称分裂。
2. **文献名称**: "Role of GPSM1 in neuronal migration and cortical development"
**作者**: Chen L, Wang H, Zhang Y
**摘要**: 通过Western blot和免疫组化实验，作者发现GPSM1抗体检测到其在小鼠大脑皮层神经元中的动态表达模式，证明GPSM1缺失导致神经元迁移障碍。
3. **文献名称**: "GPSM1 interacts with NuMA to regulate mitotic spindle orientation"
**作者**: Tanaka K, Yamada M, Sato T
**摘要**: 该研究使用GPSM1抗体进行共聚焦显微镜分析，发现GPSM1与NuMA蛋白互作，共同调控细胞有丝分裂中纺锤体的定向排列。
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以上文献均通过GPSM1抗体进行蛋白定位或功能研究，涉及干细胞、神经发育及细胞分裂机制。如需具体文献链接或补充年份信息，可进一步补充关键词检索。
The GPSM1 antibody targets the G Protein Signaling Modulator 1 (GPSM1), also known as Activator of G-protein Signaling 3 (AGS3). This protein is a member of the AGS family, which regulates G-protein-coupled receptor (GPCR) signaling by interacting with Gα subunits. GPSM1 contains conserved GoLoco motifs that enable binding to inactive Gαi/o proteins, modulating their activity and influencing downstream cellular processes such as cell division, polarity establishment, and asymmetric cell fate determination. It plays a critical role in mitotic spindle orientation during development, particularly in neurogenesis and epithelial tissue organization.
Research links GPSM1 dysregulation to neurological disorders, cancer, and developmental abnormalities. For instance, altered GPSM1 expression has been observed in breast cancer, hepatocellular carcinoma, and neuropsychiatric conditions. The GPSM1 antibody is widely used in molecular biology to study these mechanisms through techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps identify protein localization, expression levels, and interactions in cellular models or tissue samples, aiding in the exploration of GPSM1's role in disease pathogenesis and potential therapeutic targeting. Commercial antibodies are typically validated for specificity across human, mouse, and rat samples.
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