| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GPBP; SSH6; VASCULIN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GPBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPBP1抗体的3篇示例性参考文献(注：GPBP1相关研究较少，部分文献可能为虚构示例，建议通过学术数据库核实)：
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1. **标题**: *Autoantibodies against GPBP1 in systemic autoimmune diseases*
**作者**: Martinez-Martinez P, et al.
**摘要**: 研究报道了GPBP1作为自身抗原在系统性红斑狼疮(SLE)患者血清中的免疫反应性，发现抗GPBP1抗体与疾病活动性相关，提示其可能参与自身免疫病理机制。
2. **标题**: *GPBP1 regulates cell motility through antibody-mediated functional inhibition*
**作者**: Smith J, et al.
**摘要**: 通过开发特异性GPBP1抗体，揭示了GPBP1蛋白在细胞迁移中的关键作用，抗体阻断实验表明其通过调控细胞骨架重组影响肿瘤细胞侵袭性。
3. **标题**: *Development of a monoclonal antibody for GPBP1 detection in human tissues*
**作者**: Lee S, Kim D.
**摘要**: 研究成功制备了高特异性抗GPBP1单克隆抗体，验证了其在免疫组化中的应用，发现GPBP1在多种癌症组织中高表达，可能作为潜在生物标志物。
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**注意**：以上文献为模拟示例，实际研究中GPBP1(Glycogen Phosphorylase Brain Form 1)的相关抗体研究较少，建议通过PubMed或Google Scholar以“GPBP1 antibody”或“GPBP1 autoantibody”为关键词检索最新文献。若目标蛋白为“CERT”(Ceramide Transfer Protein，别名GPBP)，可调整关键词扩大搜索范围。
The GPBP1 (G Protein Pathway Suppressor 1) antibody is a crucial tool in studying the role of GPBP1. a protein implicated in modulating G-protein-coupled receptor (GPCR) signaling pathways. GPBP1. also known as GPS1. functions as a negative regulator of Gβγ subunits, influencing cellular processes such as proliferation, differentiation, and apoptosis. It is part of the suppressor of morphogenesis in genitalia (SMG) complex, which regulates mRNA surveillance and nonsense-mediated decay. Dysregulation of GPBP1 has been linked to cancer, immune disorders, and neurological diseases, making its study vital for understanding disease mechanisms.
The GPBP1 antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It is widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect GPBP1 expression, localization, and interaction partners in cell lines or tissues. Validations often include knockout controls to confirm specificity. Researchers employ this antibody to explore GPBP1's role in GPCR signaling crosstalk, stress responses, and tumorigenesis. Its clinical relevance extends to potential biomarker discovery and therapeutic targeting, particularly in cancers where GPBP1 overexpression correlates with metastasis or drug resistance. However, interpretation requires caution due to potential post-translational modifications affecting antibody binding.
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