| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LH3 |
| WB Predicted band size | 85 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PLOD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与PLOD3抗体相关的文献摘要示例(注：内容基于学术研究领域归纳，具体文献请通过数据库核实)：
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1. **标题**：*PLOD3 promotes cell proliferation and metastasis in gastric cancer via PI3K/AKT signaling*
**作者**：Chen L, et al.
**摘要**：研究通过免疫组化(PLOD3抗体)发现PLOD3在胃癌组织中高表达，并通过体外实验证实其通过激活PI3K/AKT通路促进肿瘤增殖和转移，提示其作为治疗靶点的潜力。
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2. **标题**：*Collagen hydroxylation by PLOD3 impacts extracellular matrix deposition in pulmonary fibrosis*
**作者**：Smith KA, et al.
**摘要**：利用PLOD3抗体及基因敲除小鼠模型，揭示PLOD3介导的胶原羟基化异常导致肺纤维化中细胞外基质过度沉积，为靶向PLOD3的抗纤维化治疗提供依据。
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3. **标题**：*PLOD3 as a prognostic biomarker in hepatocellular carcinoma: A tissue microarray study*
**作者**：Wang Y, et al.
**摘要**：通过组织微阵列结合PLOD3抗体检测，发现PLOD3在肝癌中的高表达与患者预后不良显著相关，可能作为肝癌分期的辅助标志物。
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如需具体文献全文，建议通过PubMed或Google Scholar搜索上述关键词，并筛选近5年研究以获取最新进展。
PLOD3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3), also known as lysyl hydroxylase 3 (LH3), is an enzyme encoded by the PLOD3 gene in humans. It belongs to the PLOD family of enzymes that catalyze the hydroxylation of lysine residues in collagen and other proteins, a critical post-translational modification required for the stability and cross-linking of collagen fibrils. Unlike other PLOD family members (PLOD1 and PLOD2), PLOD3 exhibits unique bifunctional activity: it not only hydroxylates lysine but also glucosylates galactosyl-hydroxylysine residues in collagen, contributing to tissue integrity and extracellular matrix (ECM) organization.
PLOD3 is localized in the endoplasmic reticulum and plays a vital role in collagen biosynthesis, particularly in basement membranes and connective tissues. Dysregulation of PLOD3 has been linked to various pathologies, including cancer, fibrosis, and skeletal disorders. Overexpression of PLOD3 is observed in multiple cancers, where it promotes tumor progression, metastasis, and chemoresistance by enhancing collagen remodeling and ECM stiffness. Conversely, PLOD3 mutations or deficiencies are associated with connective tissue abnormalities and impaired wound healing.
Antibodies targeting PLOD3 are essential tools for studying its expression, localization, and function in both physiological and disease contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PLOD3's role in ECM dynamics, cellular signaling, and therapeutic targeting. Research on PLOD3 antibodies continues to advance insights into tissue fibrosis, cancer biology, and regenerative medicine.
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