| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | TAPL, EST122234 |
| WB Predicted band size | 84 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCB9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCB9抗体的3篇参考文献示例(注：以下文献为模拟内容，实际引用请核实真实来源)：
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1. **文献名称**: *ABCB9 mediates lysosomal transport of phospholipids through interactions with the LIMP-2/SCARB2 complex*
**作者**: Ishikawa, T., et al.
**摘要**: 本研究利用特异性ABCB9抗体进行免疫荧光和免疫印迹分析，揭示了ABCB9在溶酶体膜上的定位。通过基因沉默和抗体阻断实验，发现ABCB9与LIMP-2蛋白相互作用，调控溶酶体内磷脂代谢，提示其在细胞内脂质稳态中的作用。
2. **文献名称**: *Differential expression of ABCB9 in colorectal cancer and its correlation with chemoresistance*
**作者**: Müller, S., et al.
**摘要**: 通过ABCB9抗体对结直肠癌组织进行免疫组化分析，发现ABCB9在化疗耐药患者中显著高表达。功能实验表明，ABCB9过表达通过调节溶酶体药物外排增强癌细胞耐药性，提示其作为潜在治疗靶点。
3. **文献名称**: *Generation and characterization of ABCB9 knockout mice using antibody-based phenotypic validation*
**作者**: Velarde, G., et al.
**摘要**: 研究构建了ABCB9基因敲除小鼠模型，利用Western blot和免疫组化抗体验证蛋白表达缺失。表型分析显示，ABCB9缺失导致溶酶体功能异常和脂质积累，支持其在脂质代谢中的关键作用。
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**备注**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar检索最新文章。若需具体文献，可提供更详细的研究方向以便进一步筛选。
ABCB9. a member of the ATP-binding cassette (ABC) transporter superfamily, is a transmembrane protein primarily localized to lysosomal membranes. It functions as an ATP-dependent transporter, facilitating the movement of specific substrates across membranes, though its exact physiological substrates remain under investigation. ABCB9 is structurally characterized by two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs), typical of ABC transporters, which hydrolyze ATP to drive substrate translocation. It is implicated in lysosomal homeostasis, potentially participating in antigen processing, peptide transport, or lipid metabolism, with studies suggesting a role in maintaining cellular stress responses.
ABCB9 antibodies are critical tools for detecting and quantifying ABCB9 protein expression in research. They enable the study of its subcellular localization, expression patterns across tissues, and regulatory mechanisms under physiological or pathological conditions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Dysregulation of ABCB9 has been explored in cancer, neurodegenerative diseases, and lysosomal storage disorders, with its expression occasionally linked to drug resistance or disease progression. ABCB9 knockout models and inhibitor studies further rely on these antibodies to validate protein knockdown or functional inhibition. Despite progress, the precise biological roles of ABCB9 and its relevance to human diseases remain areas of active research, highlighting the continued importance of high-specificity antibodies in unraveling its molecular and therapeutic significance.
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