| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | C10, Scya6, MRP-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of mouse Ccl6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Ccl6抗体的3篇参考文献示例(注：文献为模拟示例，非真实存在)：
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1. **文献名称**：*CCL6 Drives Tumor-Associated Macrophage Polarization in Colorectal Cancer*
**作者**：Kim J, et al.
**摘要**：该研究通过免疫组化和小鼠模型，利用Ccl6特异性抗体揭示其在肿瘤微环境中促进巨噬细胞向促癌M2表型转化的作用，并证实阻断Ccl6可抑制肿瘤生长。
2. **文献名称**：*Neutralizing CCL6 Antibody Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis*
**作者**：Wang L, et al.
**摘要**：研究者使用Ccl6中和抗体干预多发性硬化小鼠模型，发现其显著减少中枢神经系统内炎症细胞浸润及脱髓鞘病变，表明Ccl6是神经炎症的关键调节因子。
3. **文献名称**：*CCL6 Modulates Fibroblast Activation in Pulmonary Fibrosis via Chemokine Signaling*
**作者**：Gomez I, et al.
**摘要**：通过Western blot和流式细胞术结合Ccl6抗体，该研究证明肺纤维化模型中成纤维细胞高表达Ccl6.抗体阻断后胶原沉积减少，提示其作为治疗靶点的潜力。
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以上示例展示了Ccl6抗体在不同疾病模型中的应用，涵盖肿瘤、神经炎症及纤维化研究，重点突出抗体在机制探索或治疗干预中的作用。
**Background of CCL6 Antibody**
CCL6 (C-C motif chemokine ligand 6), also known as C10 or MRP-1 (myeloid-related protein 1), is a small secretory protein belonging to the CC chemokine family. It functions as a chemoattractant for immune cells, including monocytes, macrophages, and neutrophils, by interacting with receptors such as CCR1. CCR2. and CCR3. CCL6 is primarily studied in murine models, where it plays roles in inflammatory responses, tissue remodeling, and immune regulation. It is implicated in diseases like cancer, fibrosis, and autoimmune disorders, where it modulates immune cell infiltration and microenvironment dynamics.
CCL6 antibodies are tools used to detect and quantify CCL6 protein expression in experimental settings. They enable researchers to study CCL6's spatial and temporal distribution in tissues, its secretion patterns, and its functional interactions in vitro and in vivo. These antibodies are critical for techniques such as Western blotting, immunohistochemistry, flow cytometry, and ELISA. Neutralizing CCL6 antibodies can also block its activity, helping to dissect its role in disease pathways or therapeutic contexts.
Notably, while CCL6 is well-characterized in mice, its human ortholog, CCL23. shares structural and functional similarities but differs in gene regulation and disease associations. This distinction highlights the importance of species-specific antibody validation in translational research. Overall, CCL6 antibodies serve as essential reagents for exploring chemokine-mediated immunity and inflammation.
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