首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CCL26 Antibody

  • 中文名: CCL26抗体
  • 别    名: IMAC, TSC-1, MIP-4a, SCYA26, MIP-4alpha
货号: IPDX03803
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesIMAC, TSC-1, MIP-4a, SCYA26, MIP-4alpha
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CCL26
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

参考文献

以下是关于CCL26抗体的3篇参考文献示例(注:内容为模拟,非真实文献):

1. **文献名称**: *"CCL26 regulates eosinophil recruitment in allergic inflammation through CCR3 signaling"*

**作者**: Smith J, et al.

**摘要**: 研究通过抗CCL26抗体的中和实验,发现CCL26通过结合CCR3受体介导嗜酸性粒细胞向过敏性炎症部位迁移,提示其在哮喘和过敏性皮炎中的关键作用。

2. **文献名称**: *"Therapeutic targeting of CCL26 in fibrosis: Insights from antibody-based inhibition in murine models"*

**作者**: Lee H, et al.

**摘要**: 利用抗CCL26单克隆抗体阻断小鼠模型中的CCL26活性,显著减轻了肺和肝纤维化,表明CCL26抗体在抗纤维化治疗中的潜在应用价值。

3. **文献名称**: *"Expression profiling of CCL26 in tumor-associated macrophages and its role in cancer progression"*

**作者**: Wang Y, et al.

**摘要**: 通过免疫组化和流式细胞术结合CCL26抗体,发现肿瘤微环境中CCL26高表达于M2型巨噬细胞,并通过促进血管生成加速肿瘤转移。

---

**备注**: 以上文献为示例,实际引用需根据具体研究通过PubMed或学术数据库检索。

背景信息

CCL26. also known as eotaxin-3. is a chemokine belonging to the CC subfamily that plays a critical role in recruiting immune cells, particularly eosinophils, by binding to the CCR3 receptor. It is implicated in inflammatory and allergic conditions, including asthma, atopic dermatitis, and eosinophilic disorders. The CCL26 antibody is a laboratory tool designed to specifically detect, quantify, or neutralize CCL26 protein in biological samples. These antibodies are typically monoclonal or polyclonal, generated through immunization of host animals with recombinant CCL26 or peptide fragments. They are widely used in research applications such as ELISA, Western blotting, immunohistochemistry, and flow cytometry to study CCL26 expression patterns, signaling pathways, and its role in disease pathogenesis. Recent studies highlight CCL26's involvement in fibrotic diseases and cancer, expanding its clinical relevance. Antibodies targeting CCL26 also hold therapeutic potential, with investigations exploring their ability to block eosinophil migration in allergic inflammation. Validation of CCL26 antibodies includes specificity checks against related chemokines (e.g., CCL11. CCL24) and functional assays to confirm neutralization efficacy. As a biomarker, CCL26 levels are increasingly measured in clinical samples, underscoring the importance of reliable antibodies for diagnostic development.

客户数据及评论

折叠内容

大包装询价

×