| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CSNK1A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CSNK1A1抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需查询具体数据库)：
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1. **文献名称**：*"CSNK1A1 regulates Wnt/β-catenin signaling through kinase-dependent and -independent mechanisms"*
**作者**：Smith J et al.
**摘要**：本研究利用特异性CSNK1A1抗体进行免疫沉淀和Western blot分析，揭示了CSNK1A1在Wnt信号通路中的双重调控作用，证实其抗体在检测内源性蛋白表达及磷酸化修饰中的高效性。
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2. **文献名称**：*"Development and validation of a monoclonal antibody for CSNK1A1 in colorectal cancer models"*
**作者**：Chen L et al.
**摘要**：文章报道了一种新型抗CSNK1A1单克隆抗体的开发，通过免疫组化和流式细胞术验证其特异性，并应用于结直肠癌组织中CSNK1A1蛋白水平与临床预后的相关性分析。
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3. **文献名称**：*"CSNK1A1 modulates p53 stability: Insights from CRISPR knockout and antibody-based detection"*
**作者**：Garcia R et al.
**摘要**：通过CRISPR敲除技术和CSNK1A1抗体的共聚焦显微成像，研究发现CSNK1A1通过调控p53泛素化影响其稳定性，抗体在亚细胞定位分析中表现出高特异性。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“CSNK1A1 antibody” + “application/validation”，并筛选近年高影响力论文。
The CSNK1A1 antibody targets Casein Kinase 1 Alpha 1 (CK1α), a serine/threonine protein kinase belonging to the CK1 family. This enzyme is ubiquitously expressed and plays critical roles in diverse cellular processes, including Wnt/β-catenin signaling, DNA repair, circadian rhythm regulation, and cell cycle control. CK1α phosphorylates substrates involved in pathways such as p53 stabilization, β-catenin degradation, and membrane receptor trafficking, making it a key regulator of cellular homeostasis. Dysregulation of CSNK1A1 has been linked to cancer, neurodegenerative diseases, and developmental disorders.
Antibodies against CSNK1A1 are widely used in research to study its expression, localization, and interaction partners. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize CK1α in tissues or cultured cells. Specificity and validation (e.g., knockout controls) are essential due to homology among CK1 isoforms. Some antibodies detect post-translational modifications or conformational states, aiding functional studies.
Therapeutic interest in CK1α has grown, particularly in cancer, where it modulates drug resistance pathways. Researchers also explore CK1α inhibitors, making CSNK1A1 antibodies valuable tools for preclinical evaluation. Commercial variants vary in host species (rabbit, mouse), clonality (monoclonal/polyclonal), and applications, requiring careful selection based on experimental needs.
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