| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MIF; MIS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human AMH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLDN8抗体的3篇参考文献示例(注：内容为模拟生成，非真实文献)：
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1. **文献名称**：*CLDN8 as a Novel Biomarker in Colorectal Cancer: Correlation with Tumor Progression*
**作者**：Zhang, Y. et al.
**摘要**：本研究通过免疫组化(IHC)和Western blot技术，利用特异性CLDN8抗体分析结直肠癌组织。结果显示，CLDN8在癌组织中显著高表达，且与患者生存率降低和淋巴结转移相关，提示其可作为潜在预后标志物。
2. **文献名称**：*Development and Validation of a Rabbit Polyclonal Antibody Against Human CLDN8*
**作者**：Müller, R. et al.
**摘要**：文章描述了一种兔源多克隆CLDN8抗体的开发，并通过免疫荧光、流式细胞术验证其特异性。该抗体成功应用于检测肠上皮细胞和癌细胞系中的CLDN8表达，为肠道屏障功能研究提供了工具。
3. **文献名称**：*CLDN8 Dysregulation in Inflammatory Bowel Disease: Insights from Antibody-Based Profiling*
**作者**：Chen, L. & Tanaka, K.
**摘要**：研究利用CLDN8抗体分析炎症性肠病(IBD)患者肠黏膜样本，发现CLDN8表达水平与疾病严重程度呈负相关，表明其在肠上皮屏障修复中可能起关键作用。
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如需获取真实文献，建议通过PubMed或Google Scholar搜索关键词“CLDN8 antibody”或“CLDN8 claudin 8”，并筛选近年研究。
The CLDN8 antibody is a research tool targeting claudin-8 (CLDN8), a member of the claudin family of transmembrane proteins critical for forming tight junctions in epithelial and endothelial cells. Tight junctions regulate paracellular permeability, maintaining cell polarity and barrier integrity. CLDN8. encoded by the *CLDN8* gene, is primarily expressed in tissues such as the gastrointestinal tract, kidneys, and lungs, where it contributes to ion selectivity and epithelial barrier function. Its dysregulation has been linked to pathologies, including inflammatory bowel disease (IBD), renal disorders, and cancers.
In cancer research, CLDN8 expression varies by tissue type and tumor stage. For instance, it is downregulated in colorectal and gastric cancers, correlating with poor prognosis and metastasis, but upregulated in certain ovarian and breast cancers, suggesting context-dependent roles. CLDN8 antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study its localization, expression patterns, and interactions with other tight junction proteins.
Recent studies also explore CLDN8 as a therapeutic target. In IBD models, modulating CLDN8 expression could restore barrier function, while in cancer, its suppression or over_expression (depending on context) might influence tumor progression. However, challenges remain in understanding its precise mechanistic roles. CLDN8 antibodies thus serve as vital tools for both basic research and translational studies, bridging gaps between molecular biology and clinical applications.
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