| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | DORV, DTGA3 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GDF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GDF1抗体的参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询验证)：
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1. **文献名称**: "GDF1 in Cardiac Development: Antibody Localization and Functional Analysis"
**作者**: Smith A, et al.
**摘要**: 该研究利用GDF1特异性抗体，通过免疫组织化学技术分析小鼠胚胎心脏发育过程中GDF1蛋白的表达模式，发现其在心肌细胞分化中起关键作用，并验证了抗体在体外功能实验中的可靠性。
2. **文献名称**: "Role of GDF1 in Tumor Metastasis: Insights from Antibody-Based Detection"
**作者**: Chen L, et al.
**摘要**: 研究采用GDF1抗体进行Western blot和免疫组化分析，发现GDF1在多种癌症组织中高表达，且与肿瘤转移相关。抗体特异性验证表明其适用于临床样本的蛋白水平检测。
3. **文献名称**: "GDF1 as a Biomarker in Neurodegenerative Diseases: ELISA Validation Using Specific Antibodies"
**作者**: Johnson R, et al.
**摘要**: 通过开发高灵敏度的GDF1抗体，建立ELISA检测方法，发现阿尔茨海默病患者脑脊液中GDF1水平显著升高，提示其可能作为神经退行性病变的生物标志物。
4. **文献名称**: "Technical Challenges in GDF1 Antibody Development for Functional Studies"
**作者**: Lee S, et al.
**摘要**: 综述了GDF1抗体的制备策略及常见问题，强调抗体表位特异性对功能研究的重要性，并通过敲除模型验证了多克隆抗体在信号通路分析中的有效性。
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如需实际文献，建议在PubMed、Google Scholar等平台以“GDF1 antibody”、“GDF1 protein function”等关键词检索，并筛选近年的高引用研究。
The Growth Differentiation Factor 1 (GDF1) antibody is a research tool targeting GDF1. a secreted glycoprotein within the transforming growth factor-beta (TGF-β) superfamily. GDF1 plays critical roles in embryonic development, particularly in establishing left-right asymmetry and regulating cellular differentiation. It functions as a nodal signaling pathway co-ligand, forming heterodimers with other TGF-β members like BMPs to activate SMAD-dependent signaling cascades. This interaction is vital for tissue patterning, organogenesis, and maintaining tissue homeostasis.
GDF1 antibodies are widely used to detect and quantify GDF1 expression in studies involving Western blotting, immunohistochemistry, and immunofluorescence. They enable researchers to investigate GDF1's spatial-temporal expression patterns and its involvement in developmental disorders, cardiovascular diseases, and cancer. For instance, dysregulated GDF1 has been linked to congenital heart defects, neural tube anomalies, and tumor progression, where it may exhibit dual roles as either a tumor promoter or suppressor depending on cellular context.
Despite its significance, GDF1's mechanisms remain partially understood, partly due to its complex post-translational processing and context-dependent interactions. The antibody thus serves as a key reagent in elucidating GDF1's biological functions and therapeutic potential. Validated antibodies ensure specificity for both precursor and mature GDF1 forms, supporting advancements in developmental biology and disease pathology research.
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