| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/10000 | Human,Mouse,Rat |
| Aliases | Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, GOP, OPN1MW, GCP |
| Entrez GeneID | 101060233;2652;728458 |
| WB Predicted band size | 40.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OPN1MW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human OPN1MW. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于LRP2抗体的参考文献概览：
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1. **文献名称**：*Megalin-mediated endocytosis in the proximal tubule is critical for normal kidney function*
**作者**：Willnow TE, et al.
**摘要**：该研究利用特异性LRP2抗体揭示megalin在小鼠肾近端小管内吞功能中的关键作用，发现其缺失导致蛋白尿和维生素代谢异常，证实抗体在定位和功能分析中的应用。
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2. **文献名称**：*LRP2 in astrocytes modulates neuroinflammation and Alzheimer’s disease pathology*
**作者**：Kanekiyo T, Bu G.
**摘要**：通过LRP2抗体进行免疫组化和Western blot，发现星形胶质细胞中LRP2通过调控Aβ清除影响阿尔茨海默病进程，抗体被用于验证蛋白表达及与疾病标记物共定位。
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3. **文献名称**：*Antibody-based characterization of megalin in drug-induced nephrotoxicity*
**作者**：Moestrup SK, et al.
**摘要**：研究开发高亲和力抗人LRP2单克隆抗体，应用于流式细胞术和免疫荧光，证明特定药物通过megalin介导的摄取加剧肾小管损伤，验证抗体在毒性机制研究中的可靠性。
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注：以上文献为示例，实际引用时建议通过PubMed/Google Scholar核对最新研究。
LRP2 (Low-Density Lipoprotein Receptor-Related Protein 2), also known as megalin, is a multi-ligand endocytic receptor belonging to the LDL receptor family. It is predominantly expressed in polarized epithelial cells, particularly in the kidney (proximal tubules), brain (choroid plexus), lungs, and thyroid gland. LRP2 plays critical roles in nutrient uptake, cellular signaling, and metabolic regulation by mediating the endocytosis of diverse ligands, including lipoproteins, vitamins, hormones, and signaling proteins. Its involvement in renal reabsorption of filtered proteins and vitamins (e.g., vitamin D-binding protein) underscores its importance in maintaining systemic homeostasis.
Antibodies targeting LRP2 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to investigate LRP2's role in diseases such as diabetic nephropathy, Alzheimer’s disease (via interaction with amyloid-beta), and Dent disease (linked to LRP2 mutations). Commercial LRP2 antibodies are typically raised against specific epitopes, such as extracellular or cytoplasmic domains, and validated for species reactivity (human, mouse, rat). Researchers prioritize antibodies with high specificity and minimal cross-reactivity to ensure accurate detection, given LRP2's structural homology with other LDL receptor family members. Recent studies also explore LRP2's potential as a therapeutic target, further driving demand for reliable antibodies in mechanistic and drug development research.
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