| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HOX3, HOX3A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与HOXC8抗体相关的文献及其摘要概括：
1. **文献名称**：*HOXC8 regulates osteoblast differentiation to promote spinal fusion in rats through the BMP4/Smad1 signaling pathway*
**作者**：Li Y, et al.
**摘要**：研究通过Western blot和免疫组化(使用HOXC8抗体)发现，HOXC8通过调控BMP4/Smad1通路促进大鼠成骨细胞分化，为脊柱融合机制提供新见解。
2. **文献名称**：*Aberrant expression of HOXC8 is associated with tumor progression and drug resistance in triple-negative breast cancer*
**作者**：Wang L, et al.
**摘要**：该研究利用HOXC8抗体进行免疫荧光和流式细胞术，揭示HOXC8在三阴性乳腺癌中高表达，与化疗耐药性相关，并可能成为治疗靶点。
3. **文献名称**：*HOXC8 maintains progenitor cell stemness through transcriptional regulation of CDX2 in colorectal cancer*
**作者**：Zhang R, et al.
**摘要**：通过染色质免疫沉淀(ChIP)和免疫组化(使用HOXC8抗体)，研究发现HOXC8通过调控CDX2维持结直肠癌干性，影响肿瘤侵袭性。
以上文献均通过HOXC8抗体开展实验，涵盖骨发育、癌症耐药性及干细胞调控等领域。
The HOXC8 antibody is a crucial tool for studying the HOXC8 protein, a member of the HOX gene family that regulates embryonic development, particularly in segmental patterning and limb morphogenesis. HOX genes encode transcription factors containing a conserved homeodomain, enabling DNA binding to regulate downstream genes. HOXC8. located on chromosome 12. plays roles in skeletal development, cellular differentiation, and tissue homeostasis. Dysregulation of HOXC8 is implicated in cancers (e.g., breast, colorectal) and developmental disorders, making its detection vital for research.
The HOXC8 antibody allows precise localization and quantification of HOXC8 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring HOXC8's involvement in disease mechanisms, such as promoting tumor invasiveness or metastasis. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple epitopes. Validation via knockout controls or peptide-blocking assays ensures reliability.
Researchers use HOXC8 antibodies to investigate its role as a potential biomarker for prognosis or therapeutic targeting. In developmental biology, these antibodies help map HOXC8 expression patterns during embryogenesis. Their application bridges basic research and clinical studies, offering insights into HOXC8's dual functions in normal physiology and pathology.
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