| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | FLDB; LDLCQ4 |
| Entrez GeneID | 338 |
| clone | 6G6 |
| WB Predicted band size | 516kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ApoB expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与MMP10抗体相关的研究文献示例(内容基于公开研究概括，非真实文献，仅供格式参考)：
1. **《Matrix metalloproteinase-10 (MMP10) in colorectal cancer progression: Immunohistochemical analysis using a novel monoclonal antibody》**
- **作者**: Smith A, et al.
- **摘要**: 本研究开发了一种特异性抗人MMP10的单克隆抗体，并通过免疫组化证实MMP10在结直肠癌组织中的高表达与肿瘤侵袭性和不良预后相关。
2. **《MMP10 as a biomarker in inflammatory arthritis: Validation of a polyclonal antibody-based ELISA assay》**
- **作者**: Lee B, et al.
- **摘要**: 利用多克隆抗体建立ELISA检测方法，发现类风湿性关节炎患者血清MMP10水平显著升高，提示其可作为炎症活动的潜在生物标志物。
3. **《Targeting MMP10 with inhibitory antibodies reduces fibrosis in experimental liver injury models》**
- **作者**: Chen H, et al.
- **摘要**: 通过抑制性抗体阻断MMP10活性，显著减轻小鼠肝纤维化模型中的胶原沉积，证明MMP10抗体在抗纤维化治疗中的应用潜力。
(注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索确认。)
Matrix metalloproteinase 10 (MMP10), also known as stromelysin-2. is a member of the MMP family of zinc-dependent endopeptidases that regulate extracellular matrix (ECM) remodeling. It is secreted as an inactive zymogen and activated via proteolytic cleavage, enabling its enzymatic function. MMP10 primarily targets substrates such as collagen, proteoglycans, and glycoproteins, playing roles in tissue repair, inflammation, and cellular signaling. Unlike broader-spectrum MMPs, MMP10 exhibits substrate specificity linked to processes like wound healing and epithelial regeneration.
In pathological contexts, MMP10 is implicated in chronic inflammatory diseases (e.g., arthritis, atherosclerosis), fibrosis, and cancer progression. Overexpression in tumors correlates with enhanced invasion, angiogenesis, and metastasis by degrading ECM barriers and modulating cytokine activity.
MMP10 antibodies are essential tools for detecting and quantifying MMP10 expression in research and diagnostics. These antibodies enable techniques like Western blotting, immunohistochemistry, and ELISA to study MMP10 localization, regulation, and activity in tissues or biofluids. Specific monoclonal or polyclonal antibodies help identify MMP10's role in disease mechanisms, aiding therapeutic target validation. Recent studies also explore MMP10 as a biomarker for conditions like chronic obstructive pulmonary disease (COPD) and certain cancers. However, cross-reactivity with other MMPs requires careful antibody validation to ensure specificity in experimental models.
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