| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | ACTHR |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MC2R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MC2R(黑皮质素2受体)抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*Development and characterization of a specific melanocortin 2 receptor antibody*
**作者**：Clark AJL, et al.
**摘要**：该研究报道了一种针对MC2R的高特异性多克隆抗体的开发，并验证了其在肾上腺组织中的免疫定位能力。抗体通过肽段免疫动物制备，可用于检测肾上腺皮质细胞中MC2R的蛋白表达水平。
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2. **文献名称**：*Functional characterization of MC2R mutations causing familial glucocorticoid deficiency using a novel antibody-based assay*
**作者**：Harno E, et al.
**摘要**：研究利用特异性MC2R抗体建立了一种体外检测系统，分析导致家族性糖皮质激素缺乏症(FGD)的MC2R突变体功能。发现部分突变导致受体表达减少或细胞膜定位异常，揭示其病理机制。
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3. **文献名称**：*Melanocortin 2 receptor accessory protein (MRAP) regulates trafficking and signaling of MC2R in adrenal cells*
**作者**：Metherell LA, et al.
**摘要**：通过免疫共沉淀和免疫荧光技术结合MC2R抗体，证明MRAP蛋白对MC2R的细胞膜转运及ACTH信号传导至关重要，为肾上腺功能不全的分子机制提供了新见解。
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*注：以上文献信息为示例性概括，实际引用需核对具体论文细节。如需最新研究，建议在PubMed或Google Scholar中检索关键词“MC2R antibody”或“melanocortin 2 receptor antibody”。*
The melanocortin 2 receptor (MC2R), also known as the adrenocorticotropic hormone (ACTH) receptor, is a G protein-coupled receptor (GPCR) primarily expressed in the adrenal cortex. It plays a critical role in regulating steroidogenesis by binding ACTH, a pituitary-derived hormone, to stimulate cortisol production via the cAMP-PKA signaling pathway. Dysregulation of MC2R is linked to adrenal disorders such as familial glucocorticoid deficiency (FGD) and Cushing’s syndrome, highlighting its importance in endocrine homeostasis.
MC2R antibodies are essential tools for studying receptor expression, localization, and function in adrenal tissues or cell models. They enable detection of MC2R in techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding research on adrenal pathophysiology or drug screening. Some antibodies target extracellular domains to investigate ligand-receptor interactions, while others focus on intracellular regions to study downstream signaling.
Structurally, MC2R requires the melanocortin receptor accessory protein (MRAP) for proper trafficking and ACTH binding—a unique feature among melanocortin receptors. This complexity makes MC2R antibodies valuable for probing receptor-protein interactions and post-translational modifications. Emerging therapeutic strategies, such as MC2R-targeted agonists or antagonists, also rely on antibody-based validation to modulate receptor activity in conditions like adrenal insufficiency or hypercortisolism.
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