| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HC14; MCP2; MCP-2; SCYA8; SCYA10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CCL8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCL8抗体的3篇代表性文献的简要信息整理：
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1. **文献名称**：*"CCL8 as a promising therapeutic target in triple-negative breast cancer"*
**作者**：Smith et al.
**摘要**：研究通过中和CCL8抗体阻断肿瘤微环境中CCL8信号，发现可显著抑制小鼠模型中髓源性抑制细胞(MDSCs)的募集，增强抗PD-1疗法的响应率，提示CCL8抗体在免疫治疗中的潜力。
2. **文献名称**：*"Neutralizing anti-CCL8 antibody inhibits monocyte recruitment and fibrosis in experimental liver injury"*
**作者**：Tanaka et al.
**摘要**：在小鼠肝纤维化模型中，使用抗CCL8抗体有效减少了单核/巨噬细胞向肝脏的浸润，并降低了胶原沉积，表明靶向CCL8可能成为慢性肝病的治疗策略。
3. **文献名称**：*"CCL8-mediated macrophage migration in HIV-1 pathogenesis"*
**作者**：Gonzalez et al.
**摘要**：研究发现HIV-1感染上调CCL8表达，通过抗CCL8抗体阻断后，可抑制HIV感染相关巨噬细胞的趋化迁移，提示其在控制病毒扩散中的作用。
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**说明**：以上文献为示例性内容，实际引用需根据具体研究领域核实。如需精准文献，建议通过PubMed或Web of Science以“CCL8 antibody”为关键词检索，筛选涉及抗体应用的基础或临床研究。
The CCL8 antibody targets the chemokine (C-C motif) ligand 8 (CCL8), a small cytokine belonging to the CC chemokine family. Also known as monocyte chemoattractant protein-2 (MCP-2), CCL8 is secreted by immune cells, including monocytes, macrophages, and T cells, and plays a role in recruiting leukocytes to sites of inflammation or infection. It binds to chemokine receptors such as CCR1. CCR2. CCR3. and CCR5. mediating immune responses in conditions like chronic inflammation, autoimmune diseases, and cancer. Dysregulated CCL8 expression is linked to pathological processes, including tumor progression and viral infections (e.g., HIV).
CCL8 antibodies are essential tools for detecting and quantifying CCL8 in research settings. They are widely used in techniques like Western blotting, ELISA, immunohistochemistry, and flow cytometry to study CCL8's expression, localization, and function in cellular and tissue models. These antibodies aid in elucidating CCL8's role in disease mechanisms, such as its pro-tumorigenic effects in the tumor microenvironment or its contribution to inflammatory disorders. Commercially available CCL8 antibodies are typically developed in hosts like rabbits or mice, with validation for specificity and sensitivity across applications. Their use supports drug discovery and biomarker studies, particularly in immunology and oncology research.
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