| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ST3, SL-3, STMY3 |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MMP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MMP11抗体的3篇模拟参考文献示例(非真实文献，仅供格式参考)：
1. **"MMP11 as a prognostic biomarker in triple-negative breast cancer: Immunohistochemical analysis using a novel monoclonal antibody"**
- **作者**: Smith A, et al.
- **摘要**: 本研究开发了一种高特异性抗MMP11单克隆抗体，并通过免疫组化分析发现，MMP11在三阴性乳腺癌组织中高表达与患者总生存期缩短显著相关，提示其作为预后标志物的潜力。
2. **"Targeting MMP11 in stromal fibroblasts inhibits tumor invasion in pancreatic cancer models"**
- **作者**: Chen L, et al.
- **摘要**: 利用MMP11中和抗体阻断肿瘤微环境中癌相关成纤维细胞(CAFs)分泌的MMP11.显著抑制胰腺癌细胞侵袭和转移，揭示了MMP11在肿瘤间质对话中的关键作用。
3. **"MMP11 antibody-based ELISA assay for early detection of colorectal cancer progression"**
- **作者**: Yamada K, et al.
- **摘要**: 通过MMP11抗体建立了一种新型血清ELISA检测方法，发现结直肠癌患者血清MMP11水平与肿瘤分期及转移风险呈正相关，为无创监测疾病进展提供了工具。
4. **"MMP11 promotes epithelial-mesenchymal transition in gastric cancer: Mechanistic insights from antibody-mediated inhibition"**
- **作者**: Wang H, et al.
- **摘要**: 研究显示，MMP11抗体通过抑制MMP11的酶活性，阻断了胃癌细胞的EMT过程及下游信号通路(如TGF-β)，为靶向治疗提供了实验依据。
(注：以上文献为模拟内容，实际研究中请通过PubMed、Web of Science等平台检索真实文献。)
Matrix metalloproteinase 11 (MMP11), also known as stromelysin-3. is a member of the MMP family involved in extracellular matrix (ECM) remodeling and tissue homeostasis. Unlike other MMPs, MMP11 lacks intrinsic proteolytic activity against major ECM components but plays a role in processing bioactive molecules, influencing cell signaling and tumor microenvironment regulation. It is overexpressed in various cancers, including breast, colorectal, and pancreatic carcinomas, and is associated with tumor progression, metastasis, and poor prognosis. MMP11 is primarily secreted by stromal cells, such as cancer-associated fibroblasts, rather than tumor cells themselves, and its expression is often induced by cytokines or growth factors.
MMP11 antibodies are essential tools for studying its biological functions and clinical relevance. These antibodies enable the detection of MMP11 in tissues (via immunohistochemistry) or biological fluids (via ELISA or Western blot), aiding in cancer biomarker research and mechanistic studies. Specific monoclonal or polyclonal antibodies target distinct epitopes of MMP11. with applications in basic research, diagnostics, and therapeutic development. Validation of antibody specificity is critical, as MMPs share structural homology, and cross-reactivity may lead to false interpretations. Recent studies also explore MMP11's role in non-cancer pathologies, such as fibrosis and inflammatory diseases, expanding its potential as a therapeutic target.
×
