| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MST; MLK2; MEKK10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MAP3K10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于MAP3K10抗体的示例参考文献(部分为假设性示例，建议通过PubMed或Google Scholar核实具体文献)：
1. **文献名称**: *MAP3K10 expression and its role in pancreatic cancer progression*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性MAP3K10抗体(克隆号：AB123)通过Western blot和免疫组化分析发现，MAP3K10在胰腺癌组织中高表达，并通过调控JNK信号通路促进肿瘤侵袭转移。
2. **文献名称**: *Characterization of a novel monoclonal antibody against MAP3K10 for neurodegenerative disease research*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种高特异性MAP3K10单克隆抗体的开发与验证，该抗体可识别小鼠和人类样本中的MAP3K10蛋白，并应用于阿尔茨海默病模型脑组织的免疫荧光分析，揭示了MAP3K10与tau蛋白磷酸化的相关性。
3. **文献名称**: *MAP3K10 regulates embryonic development via ERK5 signaling: Evidence from antibody-based knockdown studies*
**作者**: Johnson R, et al.
**摘要**: 通过使用MAP3K10抗体进行免疫沉淀和功能阻断实验，研究发现MAP3K10在小鼠胚胎发育中通过ERK5通路调控心脏和神经管形成，抗体特异性经siRNA敲低验证。
4. **文献名称**: *Dysregulation of MAP3K10 in inflammatory bowel disease: Insights from antibody-based proteomic profiling*
**作者**: Wang Y, et al.
**摘要**: 该研究采用多克隆MAP3K10抗体(货号：sc-XXXX)对炎症性肠病患者肠黏膜组织进行蛋白质组学分析，发现MAP3K10表达水平与NF-κB激活及疾病严重程度呈正相关。
**注意**：以上文献名称及内容为示例性质，实际文献需通过学术数据库检索确认。建议使用关键词“MAP3K10 antibody”或“MAP3K10 + [疾病/功能]”在PubMed、Google Scholar或抗体公司数据库(如Abcam、CST)的技术文档中查找具体文献。
The MAP3K10 antibody targets mitogen-activated protein kinase kinase kinase 10 (MAP3K10), a serine/threonine kinase within the MAPK signaling pathway, which regulates cellular responses like proliferation, differentiation, and stress. Also known as MLK2 or MST, MAP3K10 activates downstream kinases (e.g., JNK, p38) through phosphorylation cascades. Structurally, it contains SH3 and leucine zipper domains, facilitating protein-protein interactions critical for signaling.
MAP3K10 is implicated in neuronal development, influencing axon guidance and synaptic plasticity. Dysregulation links it to pathologies: overexpression or mutations are observed in cancers (e.g., hepatocellular carcinoma, neuroblastoma), where it may act as an oncogene or tumor suppressor depending on context. Its role in apoptosis and inflammation also ties it to neurodegenerative and metabolic disorders.
Antibodies against MAP3K10 are vital tools for studying its expression, activation, and interactions. They enable detection via Western blot, immunohistochemistry, or immunofluorescence, helping elucidate its function in disease models or signaling networks. Some antibodies specifically recognize phosphorylated forms, aiding in pathway activity analysis. Commercial variants vary in clonality (monoclonal/polyclonal), species reactivity, and applications, necessitating validation for experimental conditions. Research using these antibodies has advanced understanding of MAP3K10's dual roles in health and disease, highlighting its therapeutic potential.
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