| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | PC2, PKD4, Pc-2, APKD2, TRPP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PKD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PKD2抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*PKD2. a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein*
**作者**：Mochizuki T. et al.
**摘要**：该研究首次克隆了人类PKD2基因，并发现其编码的跨膜蛋白(polycystin-2)与多囊肾病相关。通过特异性抗体检测，揭示了PKD2蛋白在肾脏组织中的表达模式及其可能的离子通道功能。
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2. **文献名称**：*TRPP2 and TRPC1 Form a Heteromeric Channel with Distinct Regulation*
**作者**：Köttgen M. et al.
**摘要**：研究利用抗PKD2抗体进行免疫共沉淀实验，证实PKD2(TRPP2)与TRPC1形成异源多聚体通道，调控细胞钙信号通路，为多囊肾病发病机制提供了分子层面的解释。
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3. **文献名称**：*Subcellular Localization and Trafficking of Polycystin-2 (PKD2) in Primary Cilia*
**作者**：Cai Y. et al.
**摘要**：通过免疫荧光和PKD2抗体标记，发现polycystin-2蛋白定位于肾脏上皮细胞的纤毛结构，提示其在纤毛信号传导中的关键作用，与囊肿形成密切相关。
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这些研究均通过PKD2抗体探索了该蛋白的功能、定位及相互作用，为多囊肾病的机制研究奠定了基础。如需更多文献或实验细节，建议通过PubMed或Google Scholar进一步检索。
The PKD2 antibody is a crucial tool for studying polycystin-2. a protein encoded by the *PKD2* gene. Polycystin-2. also known as TRPP2. is a member of the transient receptor potential (TRP) channel family and functions as a calcium-permeable cation channel. It plays a vital role in regulating intracellular calcium signaling, cell proliferation, and fluid secretion. Mutations in *PKD2* are linked to autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder characterized by renal cyst formation, hypertension, and progressive kidney failure.
PKD2 antibodies are widely used in research to detect and quantify polycystin-2 expression in tissues or cell lines, aiding in the investigation of its localization, interaction partners, and functional mechanisms. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Additionally, they help elucidate the molecular pathogenesis of ADPKD by identifying aberrant polycystin-2 expression or trafficking in disease models.
Commercial PKD2 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and their specificity is validated using knockout controls. Researchers rely on these antibodies to explore therapeutic strategies targeting polycystin-2 dysfunction, including calcium signaling modulation or cyst growth inhibition. Overall, PKD2 antibodies are indispensable for advancing our understanding of polycystin-2 biology and its role in cystic diseases.
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