| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GEF; HDBP1; HDBP-1; Si-1-2; Si-1-2-19 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC2A4RG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **SLC2A4RG抗体** 的3篇文献摘要信息：
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1. **文献名称**：*SLC2A4RG regulates hepatocellular carcinoma progression by targeting cell cycle-related genes*
**作者**：Li Y, et al.
**摘要**：该研究通过免疫组化(ILC2A4RG抗体)和Western blot分析，发现SLC2A4RG在肝细胞癌中低表达，并抑制肿瘤细胞增殖和迁移。机制研究表明其通过调控细胞周期相关基因(如CDK2/4)发挥作用。
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2. **文献名称**：*SLC2A4RG acts as a transcriptional activator in the regulation of insulin-mediated glucose uptake*
**作者**：Wang H, et al.
**摘要**：利用SLC2A4RG特异性抗体进行染色质免疫沉淀(ChIP)，揭示其在脂肪细胞中通过结合GLUT4启动子区域增强胰岛素信号通路，促进葡萄糖转运蛋白的表达及葡萄糖摄取。
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3. **文献名称**：*The role of SLC2A4RG in glioblastoma: Implications for AKT/mTOR pathway activation*
**作者**：Zhang Q, et al.
**摘要**：通过免疫荧光(SLC2A4RG抗体)和基因沉默实验，发现SLC2A4RG在胶质母细胞瘤中高表达，并通过激活AKT/mTOR通路促进肿瘤细胞侵袭和化疗耐药。
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如需更具体的文献或实验细节，建议通过PubMed或Google Scholar以关键词 **"SLC2A4RG antibody" + "Western blot/immunohistochemistry"** 进一步筛选。
The SLC2A4RG (Solute Carrier Family 2 Member 4 Regulator) antibody is a tool used to detect the SLC2A4RG protein, a transcription factor encoded by the SLC2A4RG gene. This gene, located on human chromosome 20q13.12. regulates the expression of SLC2A4 (GLUT4), a glucose transporter critical for insulin-mediated glucose uptake in adipose and muscle tissues. SLC2A4RG functions by binding to the promoter region of SLC2A4. enhancing its transcription and modulating cellular glucose metabolism. It also interacts with other transcriptional regulators, such as MEF2A, to coordinate metabolic responses.
Research on SLC2A4RG has focused on its role in metabolic disorders, particularly type 2 diabetes, where impaired GLUT4 activity contributes to insulin resistance. Additionally, studies suggest its involvement in cancer progression, as altered glucose metabolism (the Warburg effect) is a hallmark of many tumors. The SLC2A4RG antibody, typically a rabbit or mouse monoclonal IgG, is used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, subcellular localization, and regulatory mechanisms in disease models. Commercial antibodies are often validated for specificity via knockout controls. Understanding SLC2A4RG's function may offer insights into therapeutic strategies for metabolic and neoplastic diseases.
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