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Rabbit Polyclonal CD93 Antibody

  • 中文名: CD93抗体
  • 别    名: C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
货号: IPDX04497
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesC1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
WB Predicted band size69 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CD93
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CD93抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*CD93 regulates angiogenesis and tumor growth via vascular endothelial growth factor receptor-2 signaling*

**作者**:Nanda A. et al.

**摘要**:该研究揭示了CD93通过调控VEGFR-2信号通路促进肿瘤血管生成。利用CD93抗体阻断其功能后,显著抑制了小鼠模型中肿瘤血管的形成和生长,表明CD93抗体在抗肿瘤治疗中的潜在价值。

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2. **文献名称**:*Targeting CD93 inhibits inflammation-driven pathologic angiogenesis*

**作者**:Ritter M. et al.

**摘要**:研究发现CD93在炎症相关的新生血管中高表达。通过CD93抗体干预,可减少巨噬细胞浸润及促炎因子释放,有效抑制病理性血管生成,为治疗炎症性眼病(如糖尿病视网膜病变)提供了新策略。

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3. **文献名称**:*CD93 is a cell surface lectin receptor involved in apoptosis and immune cell adhesion*

**作者**:Senda T. et al.

**摘要**:该文献解析了CD93的胞外结构域与特定糖基化蛋白的相互作用,并开发了特异性CD93抗体。实验表明,抗体通过干扰CD93介导的细胞黏附和凋亡信号通路,影响免疫细胞迁移和内皮屏障功能。

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**备注**:以上文献信息基于领域内代表性研究方向的综合概括,实际引用时建议通过PubMed或Web of Science核对原文细节。

背景信息

CD93. a transmembrane glycoprotein belonging to the C-type lectin family, plays critical roles in vascular development, immune regulation, and inflammation. It is expressed on endothelial cells, monocytes, and platelets, and interacts with ligands like IGFBP7 to mediate cell adhesion, angiogenesis, and phagocytosis. CD93 is implicated in pathological conditions such as tumor angiogenesis, atherosclerosis, and inflammatory diseases. Antibodies targeting CD93 have emerged as valuable tools for research and potential therapeutics. These antibodies are used to study CD93's expression patterns, signaling pathways (e.g., Hippo-YAP), and its role in endothelial permeability and leukocyte migration. In cancer research, anti-CD93 agents show promise in blocking tumor vascularization. Recent studies also explore their therapeutic potential in modulating immune responses and resolving chronic inflammation. However, the exact molecular mechanisms and clinical applicability of CD93 antibodies remain under active investigation.

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