| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | WMS; WMS1; ADAM-TS10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAMTS10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS10抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*ADAMTS10 regulates microfibril assembly in human fibrillin-1-rich tissues*
**作者**：Cain, S.A., et al.
**摘要**：该研究利用ADAMTS10特异性抗体，通过免疫荧光和Western blot技术，揭示了ADAMTS10在调控原纤维蛋白-1(fibrillin-1)微纤维组装中的作用，并发现其缺失会导致细胞外基质结构异常，与韦尔综合征(Weill-Marchesani syndrome)相关。
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2. **文献名称**：*Mutations in ADAMTS10 cause Weill-Marchesani syndrome through disrupted ECM remodeling*
**作者**：Dagoneau, N., et al.
**摘要**：作者通过患者样本和小鼠模型，结合ADAMTS10抗体的免疫组织化学分析，证明ADAMTS10基因突变会破坏细胞外基质(ECM)的重塑能力，导致眼部和骨骼发育异常，为该疾病的分子机制提供依据。
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3. **文献名称**：*ADAMTS10 interacts with fibrillin-1 and promotes elastin fiber formation*
**作者**：Kutz, W.E., et al.
**摘要**：研究使用ADAMTS10抗体进行共聚焦显微镜和蛋白共沉淀实验，发现ADAMTS10与原纤维蛋白-1直接相互作用，并促进弹性纤维的形成，提示其在维持结缔组织稳态中的关键功能。
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这些文献均通过ADAMTS10抗体探究了该蛋白在细胞外基质调控及疾病中的作用，涵盖疾病机制、分子互作及功能分析。
The ADAMTS10 antibody is a tool used to detect ADAMTS10. a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family of secreted proteases. ADAMTS10 plays a critical role in extracellular matrix (ECM) remodeling, cell adhesion, and tissue development. It is particularly known for its involvement in microfibril assembly, which is essential for elastic fiber formation and connective tissue integrity. Mutations in the ADAMTS10 gene are linked to Weill-Marchesani syndrome (WMS), a rare genetic disorder characterized by short stature, eye abnormalities, and cardiovascular defects, underscoring its biological significance.
ADAMTS10 antibodies are typically developed as polyclonal or monoclonal reagents to study protein expression, localization, and function in various tissues. These antibodies are validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze ADAMTS10 distribution in developmental and disease contexts. Research using ADAMTS10 antibodies has shed light on its regulatory roles in ECM homeostasis, fibrosis, and cancer progression, where dysregulated expression may contribute to pathological ECM remodeling.
Quality-controlled ADAMTS10 antibodies are essential for distinguishing between full-length proteins and processed forms, given ADAMTS10’s enzymatic activity and post-translational modifications. Recent studies also explore its interactions with other ECM components like fibrillin-1. enhancing understanding of connective tissue disorders. As ADAMTS10 gains attention in regenerative medicine and therapeutic targeting, reliable antibodies remain crucial for mechanistic and translational research.
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