| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BEDP; HEPR; CDAR1; APOBEC-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human APOBEC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于APOBEC1抗体的3篇参考文献示例(内容基于真实研究领域，具体文献需根据实际检索结果调整)：
1. **文献名称**：*APOBEC1-mediated RNA editing in human metabolic diseases*
**作者**：Smith J, et al.
**摘要**：研究利用APOBEC1特异性抗体检测其在肝脏组织中的表达水平，揭示了APOBEC1编辑功能异常与脂代谢紊乱的相关性，为代谢疾病机制提供了新见解。
2. **文献名称**：*Characterization of APOBEC1 knockout mice using immunohistochemical analysis*
**作者**：Wang L, et al.
**摘要**：通过Western blot和免疫组化技术(使用APOBEC1多克隆抗体)，验证了APOBEC1基因敲除小鼠模型的有效性，并发现其在肠道中的特异性表达缺失。
3. **文献名称**：*APOBEC1 expression in gastrointestinal cancers: A prognostic biomarker study*
**作者**：Chen R, et al.
**摘要**：采用抗APOBEC1抗体对临床样本进行免疫荧光分析，发现其高表达与结直肠癌患者预后不良相关，提示其可能作为潜在治疗靶点。
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**注**：以上文献名为示例，实际引用需通过学术数据库(如PubMed、Web of Science)检索真实文献。建议使用关键词“APOBEC1 antibody”、“APOBEC1 immunohistochemistry”等查找近期研究。
**Background of APOBEC1 Antibody**
APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1) is a member of the APOBEC family of cytidine deaminases, which play critical roles in RNA and DNA editing. Discovered for its ability to mediate site-specific RNA editing of apolipoprotein B (ApoB) mRNA, APOBEC1 catalyzes the deamination of cytidine to uridine, generating a premature stop codon that leads to the production of ApoB-48. a truncated protein essential for lipid metabolism. This editing occurs predominantly in the small intestine and liver, influencing cholesterol homeostasis and lipoprotein assembly.
APOBEC1 antibodies are essential tools for studying the expression, localization, and function of this enzyme in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect APOBEC1 in tissues or cell lines. Research has linked APOBEC1 dysregulation to diseases, including certain cancers, where its overexpression or aberrant activity may contribute to genetic instability or tumor progression through off-target DNA editing.
These antibodies often target specific domains, such as the catalytic deaminase region or unique peptide sequences, enabling precise detection. Both monoclonal and polyclonal variants are available, with validation in knockout models ensuring specificity. By facilitating the investigation of APOBEC1's role in RNA editing, metabolism, and disease, these antibodies support advances in understanding its therapeutic potential and pathological mechanisms.
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