| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HRG3; pro-NRG3 |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NRG3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NRG3抗体的3篇虚构示例文献(仅供参考，非真实论文)：
1. **文献名称**：*Neuregulin 3 (NRG3) Expression in Breast Cancer: A Novel Prognostic Marker*
**作者**：Smith A, et al.
**摘要**：本研究通过Western blot和免疫组化(IHC)技术，使用特异性NRG3抗体检测乳腺癌组织中NRG3的表达水平，发现NRG3高表达与患者预后不良显著相关，提示其可能作为潜在治疗靶点。
2. **文献名称**：*Developmental Regulation of NRG3 in Mouse Brain: Insights from Antibody-Based Localization*
**作者**：Chen L, et al.
**摘要**：利用抗NRG3多克隆抗体进行免疫荧光染色，揭示NRG3在小鼠胚胎及成年脑组织中的动态表达模式，尤其在皮质和海马区富集，支持其在神经突触形成中的调控作用。
3. **文献名称**：*Generation and Validation of a High-Affinity Monoclonal Antibody against Human NRG3*
**作者**：Wang X, et al.
**摘要**：报道了一种新型NRG3单克隆抗体的开发，通过ELISA和免疫沉淀验证其特异性，并应用于检测血清及细胞裂解液中的NRG3蛋白水平，为相关疾病诊断提供工具。
4. **文献名称**：*NRG3 Signaling in Pancreatic Cancer: Functional Studies via Antibody-Mediated Blockade*
**作者**：Garcia R, et al.
**摘要**：采用NRG3中和抗体阻断体外和体内模型中的NRG3信号通路，发现其可抑制胰腺癌细胞增殖和迁移，表明靶向NRG3可能具有抗肿瘤治疗潜力。
(注：以上文献为模拟示例，实际研究需参考真实数据库如PubMed或Web of Science。)
The NRG3 (Neuregulin 3) antibody is a tool used to study the protein encoded by the NRG3 gene, a member of the neuregulin family of growth factors. NRG3 functions as a signaling molecule that interacts with receptor tyrosine kinases of the ErbB family, primarily ErbB4. to regulate cell-cell communication, particularly in the nervous system and epithelial tissues. It plays roles in neural development, synaptic plasticity, and cellular differentiation. Dysregulation of NRG3 has been implicated in neuropsychiatric disorders (e.g., schizophrenia) and cancers (e.g., breast and ovarian tumors), driving interest in its molecular mechanisms.
The NRG3 antibody enables detection and quantification of NRG3 protein expression in research applications such as Western blotting, immunohistochemistry, and immunofluorescence. It helps identify tissue-specific expression patterns, post-translational modifications, and interactions with downstream signaling pathways. Researchers also use it to explore NRG3's involvement in disease pathogenesis or therapeutic targeting.
Commercial NRG3 antibodies vary in specificity, targeting distinct epitopes (e.g., extracellular or intracellular domains) or phosphorylation states. Validation using knockout controls or siRNA-mediated knockdown is critical to ensure reliability. Despite structural similarities to other neuregulins (e.g., NRG1), NRG3 exhibits unique spatiotemporal expression and functional roles, underscoring the importance of targeted antibody tools in dissecting its biological and clinical relevance.
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