| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | LY95; CD336; NKP44; NK-p44; dJ149M18.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NCR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NCR2抗体的模拟参考文献(基于已知研究方向的概括，非真实文献，仅供参考)：
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1. **标题**：*Structural basis of NCR2 recognition by a tumor-specific antibody*
**作者**：Smith A, et al.
**摘要**：本研究解析了NCR2受体的晶体结构，并开发了一种高特异性单克隆抗体，揭示了该抗体通过结合NCR2的胞外域阻断其与肿瘤配体B7-H6的相互作用，从而抑制NK细胞介导的肿瘤细胞杀伤，为癌症免疫治疗的抗体设计提供结构依据。
2. **标题**：*Anti-NCR2 antibody enhances NK cell cytotoxicity in acute myeloid leukemia*
**作者**：Wang Y, et al.
**摘要**：通过体外和动物模型实验，证明抗NCR2激动型抗体可激活NK细胞的细胞毒性功能，显著提高对急性髓系白血病细胞的清除效率，并证实其通过PI3K/Akt信号通路增强免疫突触形成，为血液肿瘤治疗提供新策略。
3. **标题**：*NCR2 as a biomarker in viral infections: Role of soluble NCR2 and neutralizing antibodies*
**作者**：Garcia-Ruiz C, et al.
**摘要**：研究发现，在慢性HCV感染患者中，血清可溶性NCR2水平升高与NK细胞功能衰竭相关，而抗NCR2中和抗体可恢复NK细胞活性，提示靶向NCR2的抗体在抗病毒免疫中的潜在应用价值。
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**注意**：以上内容为基于NCR2已知功能的模拟示例，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词“NCR2 antibody”、“NKp44(人NCR2别名) immunotherapy”等进行查询。
Natural Cytotoxicity Triggering Receptor 2 (NCR2), also known as NKp44. is a cell surface receptor predominantly expressed on natural killer (NK) cells, a key component of the innate immune system. Encoded by the *NCR2* gene, this activating receptor plays a critical role in NK cell-mediated cytotoxicity against virus-infected and malignant cells. Structurally, NCR2 belongs to the immunoglobulin superfamily, featuring a single extracellular V-type domain, a transmembrane region, and a short cytoplasmic tail that associates with adaptor proteins like DAP12 to transmit activation signals. Unlike other NCR family members (NKp30. NKp46), NKp44 is expressed only upon NK cell activation, making it a marker for functional NK subsets.
NCR2 antibodies are tools used to study receptor function or modulate NK cell activity. Research highlights its interaction with ligands such as proliferating cell nuclear antigen (PCAN) on stressed cells, viral proteins, and components of the tumor microenvironment. Dysregulated NCR2 expression is linked to impaired immune surveillance in cancers, infections, and autoimmune diseases. Therapeutic NCR2 antibodies are being explored to enhance NK cell anti-tumor responses or block pathogenic signaling. Additionally, soluble NCR2 variants and genetic polymorphisms are studied for diagnostic or prognostic value in diseases like leukemia or COVID-19. Overall, NCR2 antibodies serve as pivotal reagents in unraveling NK cell biology and advancing immunotherapeutic strategies.
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