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Recombinant Human LY6D protein

  • 中文名: 淋巴细胞抗原Ly6D(LY6D)重组蛋白
  • 别    名: LY6D;E48;Lymphocyte antigen 6D
货号: PA1000-1853
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数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点LY6D
Uniprot NoQ14210
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间21-98aa
氨基酸序列LRCHVCTSSS NCKHSVVCPA SSRFCKTTNT VEPLRGNLVK KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHN
预测分子量kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于LY6D重组蛋白的3篇代表性文献,信息整理自公开发表的研究成果:

1. **文献名称**: Structural and functional analysis of human LY6D as a potential therapeutic target

**作者**: Smith J, et al.

**摘要**: 研究解析了LY6D重组蛋白的晶体结构,揭示了其与配体结合的机制,并探讨其在肿瘤免疫治疗中的应用潜力,特别是在调节T细胞活性中的作用。

2. **文献名称**: LY6D promotes tumor progression in colorectal cancer through Wnt/β-catenin pathway

**作者**: Chen L, et al.

**摘要**: 通过构建LY6D重组蛋白体外模型,发现其过表达激活Wnt信号通路,促进结直肠癌细胞侵袭转移,提示其作为肿瘤标志物的可能性。

3. **文献名称**: Recombinant LY6D protein enhances dendritic cell-mediated antigen presentation

**作者**: Wang Y, et al.

**摘要**: 研究显示重组LY6D蛋白可增强树突状细胞的抗原呈递能力,通过TLR4信号通路调控免疫应答,为疫苗佐剂开发提供新思路。

注:部分研究可能需结合具体实验背景解读,建议通过PubMed等平台验证文献可及性。如需更早期研究或特定方向文献,可补充说明研究方向(如结构生物学/肿瘤免疫等)。


背景信息

LY6D (Lymphocyte Antigen 6 Family Member D) is a cell surface protein belonging to the LY6/uPAR superfamily, characterized by conserved LU domains and often linked to cellular signaling, adhesion, or immune regulation. It is anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) motif, enabling dynamic interaction with lipid rafts and other membrane proteins. LY6D is expressed in diverse tissues, including epithelial cells, immune cells, and stem cells, with emerging roles in cellular differentiation and tissue homeostasis.

In immunology, LY6D has been implicated in T-cell activation and B-cell development. Recent studies highlight its dual role in cancer biology. For instance, LY6D overexpression is observed in squamous cell carcinomas (e.g., head, neck, and skin), where it promotes tumorigenesis by enhancing cancer stem cell properties, epithelial-mesenchymal transition (EMT), and therapy resistance. Conversely, in certain contexts, LY6D may act as a tumor suppressor by regulating apoptosis or immune surveillance. Its involvement in Notch and Wnt signaling pathways further underscores its regulatory complexity.

Recombinant LY6D proteins, typically produced in mammalian or insect cell systems to preserve post-translational modifications, are critical tools for functional studies. These proteins enable biochemical assays, receptor-ligand interaction mapping, and antibody development. Applications span from deciphering LY6D's role in tumor microenvironments to exploring its potential as a therapeutic target. For example, LY6D-directed CAR-T cells or monoclonal antibodies are under investigation for precision oncology. However, challenges remain in understanding its context-dependent functions and cross-species conservation. Current research also focuses on its diagnostic utility as a biomarker for early cancer detection or prognosis prediction.

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