| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | GDXYM; HHG-3; SRXY7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DHH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于DHH抗体的参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**：*Desert Hedgehog (DHH) signaling in peripheral nerve sheath tumors: Immunohistochemical analysis*
**作者**：Smith A, et al.
**摘要**：本研究利用DHH特异性抗体，通过免疫组化技术检测了良性和恶性周围神经鞘瘤中DHH蛋白的表达差异，发现DHH在肿瘤微环境中可能调控雪旺细胞分化。
2. **文献名称**：*Expression of Desert Hedgehog in testicular development: A study using DHH knockout mice*
**作者**：Jones R, et al.
**摘要**：通过DHH抗体进行Western blot和免疫荧光分析，揭示了DHH蛋白在睾丸支持细胞中的动态表达模式，证实其对生殖细胞成熟的关键作用。
3. **文献名称**：*DHH antibody-based targeting in gastrointestinal stromal tumors*
**作者**：Chen L, et al.
**摘要**：开发了一种高特异性DHH单克隆抗体，并应用于临床样本检测，发现DHH在部分胃肠道间质瘤中异常高表达，提示其作为潜在治疗靶点的可能性。
4. **文献名称**：*Role of Desert Hedgehog in pancreatic cancer progression*
**作者**：Wang Y, et al.
**摘要**：采用DHH抗体进行组织芯片分析，结合功能实验，证实DHH通过激活下游Gli信号通路促进胰腺癌侵袭转移。
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**注意**：以上内容为模拟生成，实际文献请通过PubMed、Web of Science等平台检索关键词(如“DHH antibody”、“Desert Hedgehog immunohistochemistry”)获取。建议结合具体研究方向筛选近年高相关度论文。
The DHH (Desert Hedgehog) antibody is a crucial tool in studying the Hedgehog (Hh) signaling pathway, a conserved system vital for embryonic development, tissue homeostasis, and regeneration. DHH, one of three mammalian Hh ligands (alongside Sonic and Indian Hedgehog), is primarily expressed in gonadal tissues, Schwann cells, and peripheral nerves. It plays key roles in testicular development, spermatogenesis, and peripheral nerve myelination. Dysregulation of DHH is linked to disorders such as gonadal dysgenesis, polycystic ovary syndrome (PCOS), and certain neuropathies.
DHH antibodies enable researchers to detect and quantify DHH protein expression, map its spatial distribution in tissues via immunohistochemistry, and investigate its interactions in signaling cascades. These antibodies are essential for elucidating DHH's mechanistic roles in health and disease, including its involvement in paracrine signaling through the Patched-Smoothened receptor complex. Additionally, they aid in developing diagnostic assays and evaluating potential therapeutic agents targeting the Hh pathway in cancers or degenerative conditions. Commercial DHH antibodies are typically validated for specificity in applications like Western blotting, ELISA, and immunofluorescence, though cross-reactivity with other Hh family members remains a consideration. Ongoing research continues to refine antibody performance while exploring DHH's emerging functions in adult tissue maintenance and metabolic regulation.
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