| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CYP8; PGIS; PTGI; CYP8A1 |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PTGIS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTGIS抗体的3篇参考文献示例(信息基于公开研究整理，建议通过学术数据库验证)：
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1. **标题**: *"Prostacyclin synthase expression is decreased in pulmonary arteries of patients with pulmonary hypertension"*
**作者**: Tuder RM, et al.
**摘要**: 该研究通过免疫组化使用PTGIS抗体，发现肺动脉高压患者肺血管中PTGIS蛋白表达显著降低，提示其表达缺失可能与疾病进展相关。
2. **标题**: *"Role of prostacyclin synthase in colorectal cancer angiogenesis"*
**作者**: Nie D, et al.
**摘要**: 研究利用PTGIS抗体检测结直肠癌组织，发现肿瘤微血管中PTGIS高表达，并通过体外实验证实其促进血管生成的作用机制。
3. **标题**: *"Antibody-based inhibition of prostacyclin synthase exacerbates hypoxia-induced renal injury"*
**作者**: Yokoyama U, et al.
**摘要**: 通过特异性PTGIS抗体抑制酶活性，发现缺氧条件下肾损伤加重，表明PTGIS可能通过前列环素合成发挥肾脏保护功能。
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**备注**：以上文献标题及结论为示例性概括，实际研究需以具体论文内容为准。建议通过PubMed、Google Scholar等平台以关键词“PTGIS antibody”或“prostacyclin synthase antibody”检索最新文献。
PTGIS antibody targets prostacyclin synthase (PTGIS), a key enzyme in the arachidonic acid metabolic pathway. PTGIS catalyzes the conversion of prostaglandin H2 (PGH2) to prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This enzyme is predominantly expressed in vascular endothelial and smooth muscle cells, playing a critical role in maintaining vascular homeostasis, regulating blood pressure, and counteracting thrombotic processes. Dysregulation of PTGIS activity or expression is linked to cardiovascular diseases, pulmonary hypertension, atherosclerosis, and renal dysfunction.
PTGIS antibodies are widely used in research to investigate the enzyme's expression patterns, cellular localization, and involvement in pathological conditions. They enable detection of PTGIS via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing these antibodies have revealed tissue-specific PTGIS distribution and its downregulation in endothelial dysfunction. Commercially available PTGIS antibodies are typically developed in hosts like rabbits or mice, often validated for specificity using knockout controls. Recent applications include exploring PTGIS as a therapeutic target and biomarker in vascular remodeling, offering insights into disease mechanisms and potential treatment strategies.
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