| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DNM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNM2抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in neurons*
**作者**：Souchet et al.
**摘要**：该研究利用DNM2特异性抗体，通过免疫印迹和免疫荧光技术，揭示了DNM2基因突变导致外周神经轴突运输缺陷的机制，为Charcot-Marie-Tooth病的病理提供了分子层面的解释。
2. **文献名称**：*Dynamin 2 regulates cytotoxic granule exocytosis and NK cell-mediated tumor immunity*
**作者**：Liu et al.
**摘要**：文章通过DNM2抗体抑制实验，证明DNM2在自然杀伤(NK)细胞的颗粒胞吐过程中起关键作用，其功能异常会削弱抗肿瘤免疫反应。
3. **文献名称**：*Dynamin 2 stabilization by USP15 promotes EMT/MET-dependent tumor metastasis*
**作者**：Wang et al.
**摘要**：研究使用DNM2抗体进行组织染色和蛋白质分析，发现泛素化修饰通过调控DNM2稳定性影响上皮-间质转化(EMT)，进而促进癌症转移。
4. **文献名称**：*A novel DNM2 antibody for the diagnosis of centronuclear myopathy in patient muscle biopsies*
**作者**：Durieux et al.
**摘要**：该文献报道了一种高特异性DNM2抗体的开发，通过免疫组化技术成功诊断离心性核心病，并分析了突变DNM2蛋白在肌肉组织中的异常分布。
(注：以上文献为示例，实际引用时需核实真实存在的论文信息。)
**Background of DNM2 Antibody**
DNM2 (Dynamin-2) is a ubiquitously expressed GTPase involved in membrane remodeling processes, including endocytosis, intracellular vesicle trafficking, and organelle division. It plays a critical role in clathrin-mediated endocytosis by constricting and severing membrane necks during vesicle formation. DNM2 also regulates cytoskeletal dynamics and autophagy. Dysregulation or mutations in *DNM2* are linked to several diseases, such as centronuclear myopathy, Charcot-Marie-Tooth neuropathy, and cancers, where altered membrane trafficking contributes to pathogenesis.
DNM2 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate DNM2's role in cellular processes or disease mechanisms. Specific antibodies target distinct DNM2 isoforms or post-translational modifications, enabling precise analysis. For example, research utilizing DNM2 antibodies has revealed its interaction with proteins like amphiphysin and microtubules, as well as its phosphorylation-dependent regulatory mechanisms.
Additionally, DNM2 antibodies aid in diagnosing genetic disorders caused by *DNM2* mutations. In therapeutic contexts, they help evaluate DNM2-targeting strategies, such as inhibitory peptides or small molecules, to modulate endocytosis in cancer or neurological conditions. Overall, DNM2 antibodies are pivotal in advancing both basic research and clinical applications related to membrane dynamics and associated pathologies.
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