| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDGF; CDGF1 |
| WB Predicted band size | 67 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FUT8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于FUT8抗体的代表性参考文献摘要(基于公开信息整理，非真实文献，仅供示例参考)：
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1. **文献名称**: "FUT8-mediated core fucosylation regulates TGF-β receptor signaling and cancer metastasis"
**作者**: Zhao Y. et al.
**摘要**: 研究利用FUT8特异性抗体，通过免疫印迹和免疫组化分析，发现FUT8在多种癌症组织中高表达，并通过调控TGF-β受体核心岩藻糖基化促进上皮-间质转化(EMT)和肿瘤转移。
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2. **文献名称**: "FUT8 deficiency in mice results in defective immune regulation and autoimmune phenotypes"
**作者**: Wang X. et al.
**摘要**: 通过基因敲除小鼠模型及FUT8抗体检测，发现FUT8缺失导致调节性T细胞(Treg)功能异常，引发自身免疫反应，提示FUT8在免疫稳态中的关键作用。
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3. **文献名称**: "Antibody-based detection of FUT8 activity as a biomarker for rheumatoid arthritis progression"
**作者**: Li H. et al.
**摘要**: 开发了一种基于FUT8抗体的ELISA检测方法，发现类风湿性关节炎患者血清中FUT8活性升高，与疾病严重程度呈正相关，为临床诊断提供潜在标志物。
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4. **文献名称**: "Structural analysis of FUT8-glycosylated antibodies using monoclonal anti-FUT8 probes"
**作者**: Agrawal P. et al.
**摘要**: 利用高特异性FUT8抗体探针，结合质谱技术解析了抗体Fc段核心岩藻糖基化结构，证实其对抗体依赖细胞毒(ADCC)效应的调控机制。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“FUT8 antibody”、“FUT8 fucosyltransferase”或结合具体研究领域(如癌症、糖基化)。
**Background of FUT8 Antibody**
FUT8 (α-1.6-fucosyltransferase) is a key enzyme that catalyzes the transfer of fucose to the core N-glycans of glycoproteins via an α-1.6 linkage, a process critical for modulating protein functions such as cell signaling, immune regulation, and protein stability. Dysregulation of FUT8 activity is linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
FUT8 antibodies are essential tools for studying the expression, localization, and functional roles of FUT8 in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect FUT8 in tissues or cell lines. Monoclonal FUT8 antibodies offer high specificity, while polyclonal versions may detect broader epitopes.
Research using FUT8 antibodies has revealed its involvement in cancer progression, where elevated FUT8 expression correlates with tumor metastasis and poor prognosis, potentially due to its role in modifying growth factor receptors (e.g., EGFR, TGF-βR). Conversely, FUT8 deficiency is associated with autoimmune disorders like rheumatoid arthritis.
The development of FUT8 inhibitors or antibody-based therapies is an emerging area, highlighting FUT8 as a biomarker and therapeutic target. Validated FUT8 antibodies are crucial for advancing glycobiology research and understanding disease mechanisms linked to aberrant protein fucosylation.
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