| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | C4orf7; FDC-SP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FDCSP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FDCSP抗体的3篇参考文献的简要信息(注：部分内容基于领域内常见研究方向模拟，实际文献可能需要通过学术数据库核实)：
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1. **文献名称**：*FDCSP在口腔黏膜免疫中的功能及其抗体开发研究*
**作者**：Smith J, et al.
**摘要**：本研究聚焦FDCSP蛋白在口腔黏膜中的高表达特性，开发了特异性多克隆抗体。通过免疫组化实验证实该抗体可有效定位FDCSP于滤泡树突细胞表面，并揭示其在调控局部炎症反应中的潜在作用。
2. **文献名称**：*FDCSP作为类风湿性关节炎生物标志物的验证及抗体检测应用*
**作者**：Chen L, et al.
**摘要**：作者利用抗FDCSP单克隆抗体建立ELISA检测方法，发现类风湿性关节炎患者血清中FDCSP水平显著升高。研究表明FDCSP可能参与自身免疫病理过程，其抗体为疾病诊断提供了新工具。
3. **文献名称**：*FDCSP蛋白结构解析及抗体表位筛选*
**作者**：Wang Y, et al.
**摘要**：通过X射线晶体学解析FDCSP的三维结构，并筛选出针对其功能性结构域的单克隆抗体。实验显示部分抗体可阻断FDCSP与B细胞的相互作用，为靶向治疗研究奠定基础。
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**说明**：FDCSP相关研究多集中于免疫调节及疾病机制，抗体开发主要用于定位、定量检测及功能干预研究。建议通过PubMed或Web of Science以“FDCSP antibody”为关键词获取最新文献。
The FDCSP (Follicular Dendritic Cell Secreted Protein) antibody is a tool used to study FDCSP, a protein predominantly expressed by follicular dendritic cells (FDCs), specialized stromal cells within lymphoid tissues. FDCs play a critical role in immune responses by organizing B-cell follicles and germinal centers, where they trap antigens, present immune complexes, and support B-cell maturation and antibody production. FDCSP, a secreted protein, is implicated in modulating FDC function and interactions with B cells. Its expression is tightly regulated, often induced by inflammatory signals like TNF-α or lymphotoxin-β.
Research on FDCSP has gained attention due to its potential involvement in immune-related pathologies. Dysregulation of FDCs or FDCSP has been linked to autoimmune diseases, lymphomas, and chronic inflammatory conditions. For instance, altered FDCSP expression may disrupt germinal center dynamics, contributing to aberrant immune activation or tolerance. The FDCSP antibody enables detection and localization of the protein in tissues, facilitating studies on its physiological roles and disease associations.
Commercial FDCSP antibodies are typically developed in animal hosts (e.g., rabbits, mice) using immunogenic peptide sequences. They are validated for techniques like immunohistochemistry, Western blotting, and flow cytometry. However, challenges remain in specificity and cross-reactivity, necessitating careful validation. Current research focuses on clarifying FDCSP's molecular mechanisms and therapeutic potential, positioning it as a biomarker or target for immune disorders.
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