| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ERp28; ERp31; PDIA9; PDI-DB; C12orf8 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ERP29 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ERp29(Endoplasmic Reticulum Protein 29)的参考文献摘要示例：
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1. **文献名称**：ERp29 regulates epithelial sodium channel functional expression by promoting channel cleavage
**作者**：Zhang C, Wang G, et al.
**摘要**：该研究通过使用ERp29特异性抗体，发现ERp29通过促进ENaC(上皮钠离子通道)的蛋白水解切割过程，调节其在细胞膜上的功能性表达，揭示了其在离子通道成熟中的作用机制。
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2. **文献名称**：ERp29 forms a heterodimeric complex with HERP and regulates ER-associated degradation
**作者**：Kokame K, Agarwala KL, et al.
**摘要**：文章利用免疫共沉淀(结合ERp29抗体)证明ERp29与HERP蛋白形成复合物，协同调控内质网相关降解(ERAD)途径，影响错误折叠蛋白的清除效率。
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3. **文献名称**：Loss of ERp29 promotes breast cancer progression by regulating the TGF-β signaling pathway
**作者**：Chen CY, Hsu CC, et al.
**摘要**：通过免疫组化(ERp29抗体)和基因沉默技术，研究发现ERp29表达缺失通过激活TGF-β信号通路促进乳腺癌细胞侵袭和转移，提示其作为肿瘤抑制因子的潜在作用。
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**备注**：以上文献信息为示例性概括，具体内容需以实际发表的论文为准。建议通过PubMed或Web of Science以“ERp29 antibody”或“ERp29 function”为关键词检索最新研究。
**Background of ERP29 Antibody**
ERP29 (Endoplasmic Reticulum Protein 29 kDa), also known as ERp29. is a conserved protein disulfide isomerase (PDI)-like chaperone predominantly localized in the endoplasmic reticulum (ER). Unlike classical PDIs, ERP29 lacks a catalytic thioredoxin domain but retains structural homology, featuring two domains: a conserved N-terminal thioredoxin-like domain and a C-terminal α-helical domain. It plays a critical role in protein folding, quality control, and secretory pathway regulation, facilitating the maturation and transport of client proteins, including hormones (e.g., thyroglobulin) and membrane receptors.
ERP29 is implicated in cellular stress responses, acting as a molecular chaperone to mitigate ER stress by assisting in the correct folding of nascent proteins. Its expression is regulated by the unfolded protein response (UPR) and varies across tissues, with high levels observed in secretory cells. Dysregulation of ERP29 has been linked to diseases such as cancer, where it exhibits dual roles—acting as a tumor suppressor (e.g., in breast and prostate cancers) or promoter (e.g., in lung cancer), depending on context. It also associates with neurodegenerative disorders, potentially influencing aggregation-prone protein handling.
ERP29 antibodies are essential tools for studying its expression, localization, and interaction networks. They enable detection in immunofluorescence, Western blotting, and immunohistochemistry, aiding research into ER stress mechanisms, cancer biology, and therapeutic targeting.
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