| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | p43; HLD3; EMAP2; SCYE1; EMAPII |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human AIMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于AIMP1抗体的参考文献概览：
1. **文献名称**: *AIMP1 as a mediator of TNF-α-induced neuronal cell death*
**作者**: Kim JY, et al.
**摘要**: 研究利用AIMP1抗体在阿尔茨海默病模型中检测AIMP1蛋白表达，发现其通过激活TNF-α信号通路促进神经元凋亡，抗体特异性验证通过Western blot和免疫荧光完成。
2. **文献名称**: *AIMP1 overexpression in colorectal cancer correlates with poor prognosis*
**作者**: Lee HS, et al.
**摘要**: 通过AIMP1抗体进行免疫组化分析，发现结直肠癌组织中AIMP1高表达与患者生存率降低相关，抗体应用于组织微阵列验证其作为潜在生物标志物。
3. **文献名称**: *AIMP1 modulates autoimmune inflammation via T-cell regulation*
**作者**: Park SG, et al.
**摘要**: 研究使用AIMP1抗体在小鼠类风湿关节炎模型中检测蛋白水平，揭示AIMP1通过调节T细胞分化加剧炎症反应，抗体应用于流式细胞术和ELISA验证。
4. **文献名称**: *Development of a novel monoclonal antibody against human AIMP1*
**作者**: Zhang L, et al.
**摘要**: 报道一种新型AIMP1单克隆抗体的开发，通过免疫沉淀和质谱验证其高特异性，成功应用于细胞裂解液和血清样本中的AIMP1定量检测。
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**注**：以上内容为简化示例，实际文献需通过PubMed/Google Scholar等平台检索(如关键词"AIMP1 antibody"或"AIMP1 function")。部分研究可能侧重AIMP1功能而非抗体本身，建议结合具体实验需求筛选。
The AIMP1 (aminoacyl tRNA synthase complex-interacting multifunctional protein 1) antibody is a tool used to detect and study AIMP1. a multifunctional protein initially identified as a component of the multi-synthetase complex (MSC) involved in protein synthesis. Beyond its role in tRNA aminoacylation, AIMP1 exhibits extracellular cytokine-like activity under stress conditions, regulating inflammation, angiogenesis, and apoptosis. It is also known as EMAP II (endothelial monocyte-activating polypeptide II) or SCYE1. and its dysregulation is linked to cancer, neurodegenerative disorders, and autoimmune diseases.
AIMP1 antibodies, both monoclonal and polyclonal, are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate AIMP1’s dual intracellular and extracellular functions. These antibodies help elucidate its role in pathological processes, such as promoting apoptosis in tumor cells or modulating immune responses. Researchers often produce AIMP1 antibodies by immunizing hosts with recombinant AIMP1 protein or synthetic peptides corresponding to specific epitopes. Validation typically involves knockout cell lines or siRNA-mediated knockdown to confirm target specificity. Due to AIMP1’s structural homology with other MSC components, antibody specificity is critical to avoid cross-reactivity. Its involvement in diverse pathways makes AIMP1 a compelling target for therapeutic and diagnostic research, particularly in oncology and neuroinflammation studies.
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