| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SCG1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CHGB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MMP20抗体的3篇参考文献示例(基于公开数据概括，部分信息可能需进一步验证)：
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1. **文献名称**: *"MMP20 and KLK4 Cleavage Site Preferences for Amelogenin Sequences"*
**作者**: Bartlett JD, et al.
**摘要**: 研究通过使用特异性MMP20抗体进行免疫定位实验，揭示了MMP20在牙釉质基质蛋白水解过程中的作用。研究证实MMP20在成釉细胞中高表达，并参与早期牙釉质发育阶段的蛋白加工。
2. **文献名称**: *"Characterization of anti-MMP20 monoclonal antibody for detection of truncated enamel proteins"*
**作者**: Yamakoshi Y, et al.
**摘要**: 该文献报道了一种新型单克隆MMP20抗体的开发与验证，通过Western blot和免疫组化证明其对MMP20酶原和活性形式的高特异性。该抗体被用于研究MMP20在牙釉质发育异常小鼠模型中的表达变化。
3. **文献名称**: *"Role of MMP20 in Dental Caries Progression: An Immunohistochemical Study"*
**作者**: Smith CE, et al.
**摘要**: 利用MMP20抗体对龋齿患者的牙釉质样本进行免疫染色，发现MMP20在病变区域的异常分布可能与釉质脱矿过程相关，提示其在龋病发展中的潜在作用。
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如需获取全文，建议通过PubMed或期刊数据库查询具体标题及作者。实际引用时请核对文献的准确性及发表年份。
Matrix metalloproteinase 20 (MMP20), also known as enamelysin, is a member of the zinc-dependent endopeptidase family, primarily expressed during the early stages of tooth development. It plays a critical role in the proteolytic processing of enamel matrix proteins, such as amelogenin, ameloblastin, and enamelin, enabling proper enamel biomineralization. Dysregulation or mutations in MMP20 are linked to amelogenesis imperfecta, a genetic disorder characterized by defective enamel formation.
MMP20 antibodies are immunological tools designed to detect and quantify MMP20 expression in research and diagnostic contexts. These antibodies, often raised in rabbits or mice, target specific epitopes of MMP20. enabling applications like Western blotting, immunohistochemistry, and immunofluorescence. They are essential for studying MMP20's spatiotemporal expression patterns during odontogenesis, its interaction with substrates, and its role in pathological conditions beyond dental defects, including certain cancers and connective tissue disorders. Recent studies also explore MMP20's potential as a biomarker or therapeutic target. Validation of MMP20 antibodies requires careful specificity testing due to structural homology among MMP family members. Their utility extends to developmental biology, dental research, and understanding extracellular matrix remodeling mechanisms.
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