| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | BIRC1; NLRB1; psiNAIP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human NAIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及NAIP抗体的代表性文献摘要概括：
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1. **文献名称**：*NAIP proteins are required for cytosolic detection of bacterial flagellin and type III secretion system*
**作者**：Zhao, Y., Yang, J., Shi, J., et al.
**摘要**：该研究阐明了NAIP蛋白在小鼠巨噬细胞中识别细菌鞭毛蛋白和III型分泌系统成分的关键作用，并利用特异性NAIP抗体阻断实验，证实其通过激活NLRC4炎症小体触发免疫反应。
2. **文献名称**：*Antibody-mediated blockade of NAIP enhances host resistance to intracellular bacterial pathogens*
**作者**：Kofoed, E.M., Vance, R.E.
**摘要**：研究发现，通过NAIP抗体抑制其功能可增强宿主对沙门氏菌感染的抵抗力，揭示了NAIP在调控炎症小体过度激活中的潜在治疗靶点价值。
3. **文献名称**：*NAIP expression correlates with neuronal survival in spinal muscular atrophy*
**作者**：Roy, N., Mahadevan, M.S., McLean, M., et al.
**摘要**：该文献利用NAIP抗体检测脊髓性肌萎缩症(SMA)患者神经元中NAIP的表达水平，发现其表达缺失与疾病严重程度相关，提示NAIP抗体可作为诊断辅助工具。
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**注**：以上文献内容为示例性概括，实际文献标题及结论需通过数据库(如PubMed)检索确认。建议结合具体研究方向补充近年研究。
NAIP (NLR family apoptosis inhibitory protein) is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, which plays a critical role in innate immunity. It functions as an intracellular sensor for bacterial pathogens by recognizing specific microbial components. Structurally, NAIP contains a central NACHT domain for nucleotide binding and oligomerization, along with C-terminal leucine-rich repeats (LRRs) involved in ligand recognition.
In humans, a single NAIP gene exists, while mice possess multiple paralogs (Naip1-6) with distinct pathogen specificities. NAIP proteins detect bacterial flagellin or components of type III secretion systems (e.g., PrgJ, BsaK) from pathogens like *Salmonella* or *Legionella*. Upon ligand binding, NAIP recruits NLRC4 to form the inflammasome complex, triggering caspase-1 activation, pyroptosis, and IL-1β/IL-18 release.
NAIP antibodies are essential tools for studying inflammasome activation, protein localization, and host-pathogen interactions. Dysregulation of NAIP has been linked to diseases, including spinal muscular atrophy (SMA) due to genomic proximity to the *SMN1* gene, and inflammatory disorders. Research also explores NAIP’s role in cancer and neurodegenerative diseases. Therapeutic strategies targeting NAIP-NLRC4 signaling aim to modulate excessive inflammation or enhance pathogen clearance.
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