| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human NLRP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NLRP12抗体的3篇参考文献，按文献标题、作者和摘要内容简要概括：
1. **标题**：*NLRP12 suppresses innate immunity and inflammation in murine experimental autoimmune encephalomyelitis*
**作者**：Ahn EE, et al.
**摘要**：该研究利用NLRP12特异性抗体检测小鼠中枢神经系统中的蛋白表达，发现NLRP12通过抑制NF-κB和MAPK信号通路减轻多发性硬化模型(EAE)的炎症反应，提示其具有免疫调节功能。
2. **标题**：*Hereditary periodic fever syndrome caused by a novel NLRP12 mutation*
**作者**：Jéru I, et al.
**摘要**：研究报道了一种新型NLRP12基因突变引发的周期性发热综合征，通过Western blot和免疫荧光抗体检测患者细胞，发现突变导致NLRP12蛋白功能缺陷，加剧IL-1β等促炎因子释放。
3. **标题**：*NLRP12 regulates anti-viral immunity by modulating type I IFN signaling*
**作者**：Chen ST, et al.
**摘要**：该研究利用NLRP12敲除小鼠及特异性抗体分析，揭示NLRP12通过调控RIG-I介导的I型干扰素信号通路抑制病毒复制，在抗病毒天然免疫中发挥关键作用。
4. **标题**：*Monogenic autoinflammatory disease-associated NLRP12 mutations enhance inflammasome activation*
**作者**：Shenouda S, et al.
**摘要**：研究发现自身炎症性疾病患者的NLRP12突变体通过抗体检测显示异常寡聚化，导致炎症小体过度活化，促进caspase-1依赖的IL-1β分泌，揭示其致病机制。
(注：以上文献信息为模拟示例，实际引用时需核实真实出版物。)
NLRP12 (NACHT, LRR, and PYD domains-containing protein 12) is a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, which plays a role in innate immune responses. Primarily expressed in myeloid cells, NLRP12 functions as a regulatory protein in inflammatory signaling pathways. It modulates NF-κB and MAPK activation, often acting as a negative regulator to suppress excessive inflammation. NLRP12 also participates in inflammasome formation under specific conditions, though its role here is less characterized compared to other NLRs like NLRP3.
Mutations in the NLRP12 gene have been linked to autoinflammatory disorders, such as familial cold autoinflammatory syndrome-2 (FCAS2), highlighting its importance in immune homeostasis. NLRP12 antibodies are critical tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies (monoclonal or polyclonal) are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate NLRP12's involvement in inflammatory diseases, cancer, and microbial infections. Recent studies also explore its dual role in promoting or suppressing inflammation depending on cellular context, making NLRP12 a compelling target for therapeutic research.
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