Rabbit Polyclonal NOL8 Antibody

The NOL8 antibody targets the nucleolar protein NOL8 (nucleolar protein 8), which is implicated in ribosome biogenesis and cellular RNA metabolism. NOL8 is highly conserved across eukaryotes and localizes to the nucleolus, where it interacts with small nucleolar RNAs (snoRNAs) and participates in rRNA processing. Studies suggest its role in regulating cell proliferation, apoptosis, and stress responses. Dysregulation of NOL8 has been linked to cancers, including neuroblastoma and hepatocellular carcinoma, where its overexpression correlates with tumor progression and poor prognosis. The NOL8 antibody is widely used in research to detect protein expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps elucidate NOL8's molecular functions, particularly its involvement in ribosome assembly pathways and potential crosstalk with oncogenic signaling. Recent work also explores its interaction with viral RNA during infections, highlighting broader roles in host-pathogen interactions. As a research tool, the antibody’s specificity and reliability are critical for advancing understanding of NOL8 in both normal physiology and disease contexts.