| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ZNF900 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PLAGL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及PLAGL2抗体的研究文献摘要(文献信息为模拟示例，实际引用需核实原文)：
1. **文献名称**：*PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas*
**作者**：Zheng H. et al.
**摘要**：研究通过免疫组化(使用PLAGL2抗体)发现PLAGL2在胶质瘤干细胞中高表达，通过激活Wnt信号通路维持干细胞特性并抑制分化，提示其作为治疗靶点的潜力。
2. **文献名称**：*PLAGL2 promotes colorectal cancer metastasis via HIF-1α stabilization and EGFR signaling activation*
**作者**：Wang Y. et al.
**摘要**：利用PLAGL2特异性抗体进行Western blot和免疫荧光实验，发现PLAGL2通过稳定HIF-1α蛋白增强结直肠癌细胞侵袭能力，并与患者预后不良相关。
3. **文献名称**：*The oncogenic role of PLAGL2 in breast cancer progression and tamoxifen resistance*
**作者**：Liu X. et al.
**摘要**：通过免疫组化分析乳腺癌组织(使用抗PLAGL2抗体)，证实PLAGL2过表达与雌激素受体信号通路互作，促进肿瘤增殖和他莫昔芬耐药，机制涉及PI3K/AKT通路激活。
**备注**：以上内容为示例，实际文献需通过PubMed、Google Scholar等平台以关键词“PLAGL2 antibody”或“PLAGL2 cancer”检索确认。
The PLAGL2 (Pleomorphic Adenoma Gene-Like 2) antibody is a tool used to detect the PLAGL2 protein, a member of the PLAG family of zinc-finger transcription factors. PLAGL2 plays critical roles in regulating gene expression, particularly during embryonic development and cellular differentiation. It shares structural homology with PLAG1 and PLAGL1. characterized by a conserved N-terminal transactivation domain and C-terminal zinc-finger motifs for DNA binding. Dysregulation of PLAGL2 has been implicated in various cancers, including colorectal, breast, and glioblastoma, where it often acts as an oncogene by promoting cell proliferation, inhibiting apoptosis, or activating pathways like Wnt/β-catenin.
PLAGL2 antibodies are widely used in research to study its expression patterns, subcellular localization (nuclear or cytoplasmic), and interactions with other proteins. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore PLAGL2’s role in tumorigenesis or developmental disorders. Validation of specificity via knockout controls or siRNA silencing is essential due to potential cross-reactivity with other PLAG family members. Recent studies also highlight PLAGL2’s involvement in metabolic reprogramming and stem cell maintenance, underscoring its therapeutic and diagnostic potential. Reliable PLAGL2 antibodies are thus vital for advancing mechanistic insights into diseases linked to its aberrant activity.
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