| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ROR1; ROR2; ROR3; RZRA; NR1F1; RZR-ALPHA |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human RORA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RORA抗体的3篇参考文献示例(文献信息为虚拟模拟，仅供格式参考)：
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1. **文献名称**: *RORα regulates autoimmune inflammation by repressing Th17 cell differentiation via epigenetic modification*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用RORA抗体进行ChIP-seq和Western blot分析，揭示了RORA通过表观遗传机制抑制Th17细胞分化，从而调控自身免疫性疾病(如多发性硬化症)的炎症反应。
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2. **文献名称**: *RORα expression in breast cancer: A prognostic biomarker study using immunohistochemistry*
**作者**: Lee S, et al.
**摘要**: 通过免疫组化(RORA抗体标记)，研究发现RORA在乳腺癌组织中低表达与患者预后不良相关，提示其可能作为抑制肿瘤转移的潜在标志物。
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3. **文献名称**: *Circadian regulation of RORα in the suprachiasmatic nucleus: Antibody-based localization and functional analysis*
**作者**: Sato T, et al.
**摘要**: 使用特异性RORA抗体进行脑组织免疫荧光染色，证实RORA在视交叉上核(SCN)中呈现昼夜节律性表达，并参与调控核心生物钟基因Bmal1的转录活性。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“RORA antibody”或“RORA immunolocalization”，并筛选近年应用性研究。
RORA (Retinoic Acid Receptor-Related Orphan Receptor Alpha) is a nuclear hormone receptor that plays critical roles in regulating circadian rhythms, immune function, metabolism, and neuronal development. As a transcription factor, it binds to specific DNA response elements to activate or repress target genes, including those involved in inflammation, lipid homeostasis, and neurodevelopmental pathways. RORA dysfunction has been implicated in various diseases, such as autism spectrum disorder, bipolar disorder, cancer, and autoimmune conditions like multiple sclerosis.
RORA antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable detection of RORA protein levels in tissues or cell lines via techniques like Western blotting, immunohistochemistry, and flow cytometry. Additionally, these antibodies facilitate chromatin immunoprecipitation (ChIP) to map RORA-binding genomic regions and elucidate its regulatory networks. Commercially available RORA antibodies are typically developed using immunogenic peptide sequences from conserved regions of the protein, ensuring specificity across human, mouse, and rat homologs. Validation steps, including knockout cell line controls, are crucial to confirm antibody reliability. Research utilizing RORA antibodies continues to advance understanding of its dual roles in health and disease, particularly its crosstalk with metabolic and inflammatory signaling pathways.
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