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Rabbit Polyclonal TRIM34 Antibody

  • 中文名: TRIM34抗体
  • 别    名: IFP1; RNF21
货号: IPDX05231
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/1000-1/2000 Human,Mouse,Rat

产品详情

AliasesHGF; HSF; BSF2; IL-6; IFNB2
Entrez GeneID3569
clone6D9A1
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Monkey
ImmunogenPurified recombinant fragment of human IL-6 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于TRIM34抗体的示例参考文献(内容为模拟,建议通过学术数据库核实):

1. **标题**: "TRIM34 Restricts HIV-1 Infection by Targeting Viral Capsid for Ubiquitination"

**作者**: Li Y, et al.

**摘要**: 本研究利用TRIM34特异性抗体进行免疫共沉淀和Western blot分析,发现TRIM34通过泛素化修饰HIV-1衣壳蛋白,抑制病毒在宿主细胞内的复制,揭示了其作为宿主限制因子的新机制。

2. **标题**: "TRIM34 Modulates Type I Interferon Signaling and Antiviral Immune Response"

**作者**: Wang X, et al.

**摘要**: 通过TRIM34抗体敲低实验,研究发现TRIM34通过调控干扰素调节因子3(IRF3)的活化,增强I型干扰素通路,从而抑制RNA病毒(如VSV)的感染,为抗病毒免疫治疗提供潜在靶点。

3. **标题**: "Differential Expression of TRIM34 in Autoimmune Disorders: Insights from Antibody-Based Profiling"

**作者**: Gupta S, et al.

**摘要**: 采用TRIM34单克隆抗体对类风湿性关节炎患者组织样本进行免疫组化分析,发现TRIM34在病变关节中异常高表达,提示其可能参与自身免疫反应的调控。

4. **标题**: "Structural and Functional Characterization of TRIM34 Using Monoclonal Antibodies"

**作者**: Tanaka K, et al.

**摘要**: 本研究开发了高特异性TRIM34单克隆抗体,结合冷冻电镜技术解析了TRIM34的寡聚化结构,并证实其在体外通过泛素连接酶活性抑制逆转录病毒复制。

**注意**:以上文献信息为示例性质,实际引用时请通过PubMed、Web of Science等平台检索并核实原文。

背景信息

The TRIM34 antibody is a research tool used to study the Tripartite Motif 34 (TRIM34) protein, a member of the TRIM family of proteins characterized by conserved RING, B-box, and coiled-coil domains. TRIM34. also known as HAP33 or RNF21. is part of the type I TRIM subgroup and shares structural homology with other antiviral TRIM proteins like TRIM5α and TRIM22. It is implicated in innate immunity, particularly in interferon-mediated antiviral responses, and may act as an E3 ubiquitin ligase, modulating immune signaling pathways through protein ubiquitination. Studies suggest TRIM34 contributes to host defense against viral infections, including HIV-1. by interacting with viral capsids or regulating immune sensors. Its expression is induced by interferons and viral stimuli, highlighting its role in adaptive immune regulation. TRIM34 antibodies are utilized in Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression patterns, subcellular localization, and interactions in various cell types, including immune cells and cancer models. Research also explores its potential involvement in autoimmune diseases, cancer progression, and reproductive biology, given its expression in testes and germ cells. However, challenges remain in distinguishing its functions from closely related TRIM family members due to structural similarities and overlapping roles. These antibodies are critical for elucidating TRIM34's mechanisms in health and disease.

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