| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SMVT |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC5A6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC5A6抗体的3篇参考文献示例(文献名称、作者及摘要内容概括)：
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1. **文献名称**：*"Characterization of the human sodium-dependent multivitamin transporter (hSMVT) gene and its functional analysis in cellular uptake"*
**作者**：Prasad PD et al.
**摘要**：研究通过特异性SLC5A6抗体检测hSMVT蛋白在肠道和肾脏细胞的表达，证实其介导生物素、泛酸等维生素的钠依赖性吸收，并验证抗体在Western blot和免疫荧光中的特异性。
2. **文献名称**：*"SLC5A6/SMVT deficiency promotes metabolic dysfunction via altered lipid metabolism in murine models"*
**作者**：Subramanian VS et al.
**摘要**：利用SLC5A6敲除小鼠模型及抗体验证，发现SLC5A6缺失导致肝脏和脂肪组织维生素摄取减少，引发脂代谢紊乱，抗体用于组织切片中蛋白定位及表达水平分析。
3. **文献名称**：*"Development and validation of a monoclonal antibody against the extracellular domain of human SLC5A6 for diagnostic applications"*
**作者**：Kumar TP et al.
**摘要**：报道一种高特异性抗人SLC5A6单克隆抗体的开发，通过ELISA和免疫组化验证其在结直肠癌组织中的诊断潜力，揭示SLC5A6在肿瘤细胞中的异常高表达。
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注：以上文献信息为示例，实际文献需通过数据库(如PubMed、Google Scholar)检索关键词“SLC5A6 antibody”或“SMVT antibody”获取具体内容。
The solute carrier family 5 member 6 (SLC5A6), also known as the sodium-dependent multivitamin transporter (SMVT), is a transmembrane protein responsible for the cellular uptake of pantothenate (vitamin B5), biotin (vitamin B7), and lipoate, as well as the thyroid hormone precursor iodothyronine. It plays a critical role in maintaining cellular homeostasis by mediating sodium-dependent transport of these essential micronutrients across cell membranes. SLC5A6 is widely expressed in tissues, including the intestines, liver, kidneys, and brain, highlighting its importance in nutrient absorption and metabolic regulation.
Antibodies targeting SLC5A6 are valuable tools for studying its expression, localization, and function in both physiological and pathological contexts. They are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate tissue-specific distribution or alterations in diseases like inflammatory bowel disease, neurodegenerative disorders, and cancer. Some studies suggest SLC5A6 dysregulation may contribute to micronutrient deficiencies or metabolic disruptions. Researchers also utilize these antibodies to explore SLC5A6's interaction with pharmaceutical agents, as the transporter influences drug bioavailability. Validation of SLC5A6 antibodies typically involves knockout cell lines or tissues to confirm specificity, given potential cross-reactivity with other solute carriers. Ongoing research aims to clarify its role in disease mechanisms and therapeutic targeting.
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