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Rabbit Polyclonal SLTM Antibody

  • 中文名： SLTM抗体
  • 别    名： Met
货号: IPDX05331
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesMet
WB Predicted band size117 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human SLTM
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是模拟生成的关于SLTM抗体的参考文献示例(仅供研究参考，非真实文献)：

1. **文献名称**：*Development and Characterization of a Novel Monoclonal Antibody Targeting Human SLTM Protein*

**作者**：Chen L, et al.

**摘要**：本研究报道了一种新型小鼠单克隆抗体的开发，该抗体特异性识别人源SLTM蛋白。通过免疫印迹和免疫荧光验证了抗体在HeLa细胞中的特异性，证实SLTM在细胞核与核仁中的定位，为后续功能研究提供工具。

2. **文献名称**：*SLTM Antibody Reveals Dysregulated RNA Splicing in Breast Cancer Cells*

**作者**：Smith KA, et al.

**摘要**：利用抗SLTM抗体分析乳腺癌细胞系，发现SLTM蛋白表达水平与RNA剪接异常相关。研究表明，SLTM通过调控剪接因子结合影响肿瘤相关基因表达，提示其作为潜在治疗靶点。

3. **文献名称**：*SLTM Modulates DNA Damage Response via Interaction with PARP1: Evidence from Knockdown and Antibody-Based Assays*

**作者**：Wang Y, et al.

**摘要**：通过SLTM抗体进行免疫共沉淀实验，发现SLTM与PARP1在DNA损伤修复中存在相互作用。敲低SLTM导致细胞对辐射敏感性增加，提示其在基因组稳定性中的作用。

4. **文献名称**：*A Comparative Study of SLTM Antibody Performance in Neuronal and Non-Neuronal Tissues*

**作者**：Gomez-Ramos P, et al.

**摘要**：比较了多种商业SLTM抗体在脑组织中的特异性，发现部分抗体存在交叉反应。研究推荐使用克隆号ABX-203的抗体进行神经科学研究，并验证了SLTM在突触RNA调控中的功能。

**注意**：以上文献为模拟生成，实际研究中请通过PubMed、Google Scholar等平台检索真实文献(关键词：SLTM antibody, SAFB-like antibody)。

背景信息

The SLTM (SAFB-like transcriptional modulator) antibody targets a protein involved in transcriptional regulation and RNA processing. SLTM, a member of the scaffold attachment factor B (SAFB) family, functions as a nuclear scaffold protein that interacts with RNA polymerase II, chromatin modifiers, and other transcriptional regulators. It plays roles in gene expression control, RNA splicing, and DNA damage response. SLTM shares structural and functional similarities with SAFB1. including a conserved SAF-box domain for DNA/RNA binding and a region mediating protein-protein interactions. Studies suggest SLTM participates in hormone receptor signaling, such as estrogen receptor (ER)-mediated transcription, by acting as a co-repressor or co-activator depending on cellular context. Its involvement in RNA metabolism links it to mRNA stability and transport. SLTM antibodies are essential tools for investigating these processes via techniques like immunoprecipitation, Western blotting, and chromatin immunoprecipitation (ChIP). Dysregulation of SLTM has been implicated in cancer progression and neurological disorders, highlighting its biomedical relevance. Research using SLTM antibodies continues to uncover its dual roles in transcription-coupled genomic stability and RNA biogenesis, bridging nuclear architecture with gene expression networks.

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