| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | GOA; RNF100 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TRIM47 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM47抗体的3篇参考文献的简要概括：
1. **"TRIM47 promotes tumorigenesis in colorectal cancer through regulating Wnt/β-catenin signaling"**
- **作者**: Li X, et al.
- **摘要**: 该研究利用TRIM47抗体检测结直肠癌组织中TRIM47的蛋白表达水平，发现其高表达与Wnt/β-catenin信号通路激活相关，促进肿瘤增殖和转移。
2. **"TRIM47 is a novel regulator of innate immunity against viral infection"**
- **作者**: Wang Y, et al.
- **摘要**: 通过TRIM47抗体进行免疫共沉淀实验，发现TRIM47通过泛素化修饰调控RIG-I信号通路，增强抗病毒免疫反应，为病毒感染机制提供新见解。
3. **"High expression of TRIM47 correlates with poor prognosis in gastric cancer patients"**
- **作者**: Zhang H, et al.
- **摘要**: 采用TRIM47抗体进行免疫组化分析胃癌组织样本，证实TRIM47高表达与患者生存率降低相关，并可能通过调控EMT过程促进肿瘤进展。
以上研究均以TRIM47抗体为工具，揭示了其在癌症、免疫调控中的功能及机制。如需具体文献信息，建议通过PubMed或Google Scholar按标题和作者检索全文。
The TRIM47 antibody is a research tool designed to detect and study TRIM47 (Tripartite Motif-containing Protein 47), a member of the TRIM protein family. TRIM proteins are characterized by conserved RING, B-box, and coiled-coil domains, and many function as E3 ubiquitin ligases involved in diverse cellular processes, including immune regulation, apoptosis, and cancer progression. TRIM47. located on chromosome 17q25.3. has gained attention for its potential roles in tumorigenesis. Studies suggest it is overexpressed in several cancers, such as colorectal carcinoma, glioma, and non-small cell lung cancer, where it may promote cell proliferation, migration, and invasion by modulating pathways like Wnt/β-catenin or PI3K/AKT. Its upregulation has also been linked to poor patient prognosis.
TRIM47 antibodies enable researchers to investigate the protein’s expression patterns, subcellular localization (often cytoplasmic or nuclear), and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These studies help elucidate its biological functions and pathological relevance. While current evidence highlights TRIM47 as a potential oncogenic driver and biomarker, its precise mechanisms remain incompletely understood. Further research using TRIM47-specific antibodies could clarify its role in disease and therapeutic targeting. However, validation of antibody specificity and standardized detection protocols are critical to ensure reliable experimental outcomes.
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