| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DLK-2; EGFL9 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DLK2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DLK2抗体的3篇参考文献(示例格式，非真实文献)：
1. **"DLK2 regulates adipogenesis through Notch signaling inhibition"**
- **作者**: Smith A, et al.
- **摘要**: 研究报道了DLK2抗体在抑制前脂肪细胞分化中的作用，通过阻断Notch通路活性，证实DLK2抗体可能成为肥胖治疗的潜在工具。
2. **"Characterization of a monoclonal antibody targeting the extracellular domain of DLK2 in glioblastoma"**
- **作者**: Chen L, et al.
- **摘要**: 开发了一种特异性识别DLK2胞外结构域的单克隆抗体，验证其在胶质母细胞瘤细胞系中的靶向结合能力，并显示其抑制肿瘤生长的效果。
3. **"DLK2 modulates neural stem cell differentiation via interaction with DLL1"**
- **作者**: Tanaka R, et al.
- **摘要**: 利用DLK2多克隆抗体进行免疫沉淀实验，揭示DLK2通过竞争性结合DLL1调控神经干细胞分化的分子机制。
(注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索确认。)
The DLK2 (Delta-like 2 homolog) antibody is a tool used to study the DLK2 protein, a member of the epidermal growth factor (EGF)-like repeat-containing protein family. DLK2 shares structural homology with DLK1. including conserved EGF-like repeats and a transmembrane domain, but its biological roles remain less characterized. While DLK1 is implicated in adipogenesis, neurogenesis, and tumorigenesis, DLK2 is hypothesized to modulate similar pathways, potentially through interactions with the Notch signaling pathway or other receptor systems. However, its exact mechanisms and physiological functions are still under investigation.
DLK2 antibodies are primarily utilized in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to detect DLK2 expression patterns in tissues or cell lines. These antibodies have been critical in identifying DLK2's expression in specific cancers, stem cell populations, and developmental contexts, suggesting roles in cell differentiation and disease progression. For instance, elevated DLK2 levels have been observed in certain cancers, hinting at its potential as a biomarker or therapeutic target. Commercially available DLK2 antibodies are typically raised in hosts like rabbits or mice, with validation data confirming specificity against human, mouse, or rat DLK2 isoforms. Ongoing studies aim to clarify DLK2's interplay with DLK1 and other signaling molecules, advancing understanding of its contributions to development and pathology.
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