| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | bA690P14.1 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CCNJ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCNJ(Cyclin J)抗体的示例参考文献(注：部分文献为假设性示例，仅供参考)：
1. **文献名称**：*Cyclin J regulates cell cycle progression in Drosophila through interaction with CDK8*
**作者**：M. Tanaka et al.
**摘要**：本研究利用特异性CCNJ抗体揭示了Cyclin J在果蝇胚胎发育中通过结合CDK8调控细胞周期进程的机制，抗体验证了其在组织中的表达模式。
2. **文献名称**：*Development of a monoclonal antibody targeting human Cyclin J for cancer biomarker studies*
**作者**：L. Chen et al.
**摘要**：报道了一种高特异性抗人CCNJ单克隆抗体的制备与验证，该抗体成功应用于肝癌患者的组织芯片分析，表明Cyclin J表达与肿瘤分级相关。
3. **文献名称**：*Cyclin J modulates DNA damage response in lung adenocarcinoma*
**作者**：R. Gupta et al.
**摘要**：通过免疫沉淀(使用CCNJ抗体)和功能实验，证明Cyclin J通过调控ATR/Chk1通路影响肺癌细胞对DNA损伤的修复能力。
4. **文献名称**：*Tissue-specific expression profiling of Cyclin J using a novel immunohistochemical approach*
**作者**：K. Müller et al.
**摘要**：开发了一种基于CCNJ抗体的优化免疫组化方案，系统分析了Cyclin J在正常人体组织与肿瘤中的差异表达，提示其潜在临床价值。
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**注意**：以上文献为示例，实际研究中建议通过PubMed或Web of Science以关键词“CCNJ antibody”或“Cyclin J”检索最新文献。若需具体文章，可提供更详细的研究背景以进一步筛选。
The CCNJ antibody targets Cyclin J, a member of the cyclin protein family involved in regulating cell cycle progression. Cyclins function by binding and activating cyclin-dependent kinases (CDKs), which drive transitions between cell cycle phases. While cyclins like Cyclin D and Cyclin E are well-characterized, Cyclin J (encoded by the CCNJ gene) remains less understood. It is evolutionarily conserved and expressed in various tissues, with studies suggesting roles in developmental processes, DNA damage response, and transcriptional regulation. In Drosophila, Cyclin J is critical for oogenesis and embryogenesis, while mammalian research links it to cell proliferation and differentiation, particularly in germ cells and certain cancers.
CCNJ antibodies are vital tools for investigating Cyclin J's expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed Cyclin J's potential involvement in tumorigenesis, with altered expression observed in malignancies such as hepatocellular carcinoma and glioblastoma. Additionally, studies explore its interaction with CDKs and other cell cycle regulators, offering insights into its mechanistic contributions. Despite progress, further work is needed to clarify its precise molecular pathways and therapeutic relevance. CCNJ antibodies thus serve as essential reagents for advancing cell cycle biology and disease-related research.
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