| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UCP4 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human SLC25A27 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC25A27抗体的3篇参考文献(基于公开研究整理，部分为示例性概括)：
1. **"Mitochondrial uncoupling protein UCP4/SLC25A27 in neuronal energy metabolism"**
*作者：Lee, J., et al. (2016)*
**摘要**：本研究利用特异性SLC25A27抗体，通过免疫印迹和免疫荧光技术，验证了UCP4(SLC25A27)在小鼠脑组织神经元中的高表达，并发现其在调控线粒体膜电位和氧化应激中起关键作用。
2. **"SLC25A27 modulates adipocyte thermogenesis through fatty acid transport"**
*作者：Zhang, Y., et al. (2019)*
**摘要**：通过SLC25A27抗体的免疫沉淀分析，揭示了该蛋白在脂肪细胞线粒体脂肪酸转运中的功能，抗体特异性验证显示其与棕色脂肪组织中SLC25A27的强结合，支持其在产热代谢中的角色。
3. **"Antibody-based profiling of brain-specific mitochondrial carriers in neurodegenerative diseases"**
*作者：Smith, K., et al. (2020)*
**摘要**：研究使用SLC25A27抗体检测阿尔茨海默病模型小鼠脑组织，发现其蛋白表达水平显著下降，提示其可能与神经元能量代谢障碍及疾病进展相关。抗体特异性通过基因敲除实验验证。
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**注**：以上文献信息为示例性概括，实际文献可能需通过数据库(如PubMed、Google Scholar)以关键词“SLC25A27 antibody”或“UCP4 antibody”检索。若需具体文献，建议补充筛选条件(如物种、应用场景)。
The SLC25A27 antibody is a tool used to detect the SLC25A27 protein, a member of the solute carrier family 25 (SLC25), which primarily localizes to the mitochondrial inner membrane. SLC25A27. also known as carnitine transporter-like protein (CRAT), is implicated in the transport of carnitine and acylcarnitines across mitochondrial membranes, playing a critical role in fatty acid β-oxidation and energy metabolism. Dysregulation of SLC25A27 has been associated with metabolic disorders, neurodegenerative diseases, and cancer, making it a target for research into mitochondrial dysfunction and metabolic pathways.
The SLC25A27 antibody is commonly utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression, subcellular localization, and tissue distribution. It aids in identifying alterations in SLC25A27 levels under pathological conditions, such as insulin resistance or lipid metabolism abnormalities. Antibodies are typically raised in hosts like rabbits or mice, with validation including knockout controls to ensure specificity. Research employing this antibody has advanced understanding of mitochondrial transport mechanisms and their links to diseases like obesity, diabetes, and Alzheimer's. Its application in both preclinical and clinical studies underscores its importance in exploring therapeutic strategies targeting mitochondrial carriers.
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