| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FUCTX |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FUT10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于FUT10抗体的模拟参考文献示例(注：部分内容为假设性概括，实际文献可能需要通过学术数据库进一步验证)：
---
1. **文献名称**：*Monoclonal Antibody Against FUT10 Reveals Its Overexpression in Colorectal Cancer*
**作者**：Zhang Y. et al.
**摘要**：本研究开发了一种特异性识别FUT10蛋白的单克隆抗体，并通过免疫组化分析发现FUT10在结直肠癌组织中表达显著上调，提示其可能作为肿瘤进展的生物标志物。
2. **文献名称**：*Role of FUT10 in Stem Cell Glycosylation: Insights from Antibody-Based Functional Blockade*
**作者**：Smith J.L. et al.
**摘要**：利用FUT10抗体阻断其酶活性，揭示了FUT10介导的岩藻糖基化修饰对胚胎干细胞表面受体(如Notch)信号通路的调控作用，影响细胞分化过程。
3. **文献名称**：*Characterization of a Polyclonal FUT10 Antibody for Glycomics Research*
**作者**：Tanaka K. et al.
**摘要**：报道了一种多克隆FUT10抗体的制备与验证，通过Western blot和免疫荧光证实其特异性，并应用于肝癌细胞系中糖基化模式的研究。
---
**注意**：以上为基于FUT10相关研究的模拟示例，实际文献可能有限。建议通过PubMed或Google Scholar检索关键词“FUT10 antibody”或“FUT10 fucosyltransferase”以获取最新研究。若需具体文献，可进一步提供数据库检索支持。
FUT10 (Fucosyltransferase 10) is an enzyme belonging to the glycosyltransferase family, specifically catalyzing the transfer of fucose residues to glycoproteins and glycolipids via α1.3-linkages during post-translational modifications. It plays a critical role in synthesizing Lewis antigens and other fucosylated glycoconjugates involved in cell-cell interactions, immune responses, and signal transduction. FUT10 is primarily expressed in epithelial tissues and has been implicated in various physiological and pathological processes, including cancer progression, inflammation, and developmental regulation.
FUT10 antibodies are immunological tools designed to detect and quantify FUT10 protein expression in research applications. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression patterns, subcellular localization, and dysregulation in diseases. Such antibodies often target specific epitopes within the enzyme's catalytic domain or variable regions. Studies utilizing FUT10 antibodies have contributed to understanding its role in tumor metastasis (e.g., through modulating E-cadherin fucosylation) and congenital disorders of glycosylation. Validation of these antibodies typically includes knockout controls and activity assays to ensure specificity, given the structural similarities among fucosyltransferase family members. Their development supports ongoing exploration of FUT10 as a potential biomarker or therapeutic target in glycosylation-related diseases.
×
