| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Glucose-6-phosphate isomerase, GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Gpi, Gpi1 |
| Entrez GeneID | 14751 |
| WB Predicted band size | 62.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Gpi antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of mouse Gpi. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于INSC抗体的3篇参考文献示例(注：INSC抗体相关文献较少，以下内容为模拟概括，仅供参考)：
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1. **文献名称**：*INSC Antibody as a Novel Marker for Neural Stem Cell Identification in Glioblastoma*
**作者**：Zhang Y, et al.
**摘要**：研究验证了INSC抗体在胶质母细胞瘤中特异性标记神经干细胞的作用，发现其表达与肿瘤侵袭性和患者预后相关，提示其作为诊断工具的潜力。
2. **文献名称**：*Development and Validation of a Monoclonal INSC Antibody for Pancreatic Cancer Research*
**作者**：Smith JL, et al.
**摘要**：团队开发了一种高特异性的INSC单克隆抗体，通过免疫组化和流式细胞术验证其在胰腺癌中靶向肿瘤干细胞亚群的能力，并探索其治疗应用价值。
3. **文献名称**：*Role of INSC in Tumor Microenvironment Remodeling: Insights from Antibody-Based Inhibition Studies*
**作者**：Gupta R, et al.
**摘要**：利用INSC抗体阻断实验，揭示了INSC蛋白通过调控Wnt/β-catenin通路促进肿瘤微环境重塑的机制，为靶向治疗提供新方向。
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**说明**：INSC抗体相关研究较为小众，上述内容基于假设性文献模拟。如需真实文献，建议通过PubMed或Google Scholar检索关键词“INSC antibody”或联系领域专家获取最新进展。
The INSC (Inscuteable) antibody is a crucial tool in developmental biology and neurobiology research, targeting the Inscuteable protein—a key regulator of asymmetric cell division. First identified in *Drosophila melanogaster*, INSC acts as a scaffold protein, coordinating the orientation of mitotic spindles and ensuring proper segregation of cell fate determinants during neuroblast division. This process is vital for generating cellular diversity in developing tissues, particularly in the nervous system. Mammalian homologs of INSC (e.g., mInsc) share conserved roles in polarized cell division, impacting neurogenesis, stem cell differentiation, and tissue patterning.
The INSC antibody enables researchers to visualize protein localization, assess expression levels, and study its interaction partners via techniques like immunofluorescence, Western blotting, or co-immunoprecipitation. Its applications span investigating neurodevelopmental mechanisms, cancer biology (where asymmetric division dysregulation may drive tumor heterogeneity), and regenerative medicine. Recent studies also explore INSC's involvement in planar cell polarity and ciliogenesis, broadening its relevance to congenital disorders.
Commercial INSC antibodies are typically validated in model organisms (e.g., mice, zebrafish) and human cell lines, though species specificity requires careful verification. Ongoing research continues to uncover INSC's multifaceted roles, making this antibody indispensable for dissecting cellular polarity and developmental pathways.
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